![\"biopredictive\"](\"https:\/\/jurmed.ro\/medici\/wp-content\/uploads\/sites\/2\/2015\/05\/biopredictive-216x300.jpg\")
<\/a><\/p>\nConcep\u021bia, brevetarea c\u00e2t \u0219i primele studii clinicede validare a testelor FibroTest \u0219i FibroMax au fost efectuate de c\u0103tre o echip\u0103 de cercet\u0103tori condus\u0103 de Profesor Dr. Thierry Poynardde la Spitalul Piti\u00e9 Salp\u00eatri\u00e8re, Paris,\u00eempreun\u0103 cu echipa sa \u0219tiin\u021bific\u0103, departamentul de cercetare al BioPredictive, \u0219i o serie de parteneri \u0219tiin\u021bifici de renume din Fran\u021ba: APHP, INSERM, UPMC \u0219i CNRS. Testele au beneficiat \u0219i de contribu\u021bia unor cunoscu\u021bi consultan\u021bi \u0219tiin\u021bifici \u0219i investigatori din USA, Italia, Spania, Rom\u00e2nia, etc.<\/p>\n
\u00cenc\u0103 de la \u00eenceput, biomarkerii \u0219i algoritmii au fost selec\u021biona\u021bi pentru ca testele s\u0103 fie o alternativ\u0103 valid\u0103 pentru punc\u021bia biopsie hepatic\u0103. Ambele teste au fost validate \u00eentr-un num\u0103r mare de studii independente \u0219i prospective conduse pe cohorte numeroase: un total de 40 popula\u021bii diferite incluz\u00e2nd 7.985 de subiec\u021bi cu FibroTest \u0219i punc\u021bie biopsie hepatic\u0103 (4600 HCV, 1580 HBV, 267 NAFLD, 524 ALD \u0219i 1014 grupuri mixte).<\/p>\n
Fiecare dintre cele doua teste include trei biomarkeri serologici care sunt specifici fibrozei hepatice (Alfa2 Macroglobulina, Haptoglobina,Apolipoproteina A1), asigur\u00e2nd acurate\u021bea evalu\u0103rii fibrozei. FibroTest \u0219i FibroMax realizeaz\u0103 o foarte bun\u0103 discriminare at\u00e2t pentru stadiile incipiente \u0219i intermediare ale fibrozei c\u00e2t \u0219i pentru fibroza important\u0103 \u0219i pentru ciroz\u0103.Ambele teste au o scar\u0103 de conversie Metavir pentru exprimarea fibrozei, folosind totodat\u0103 scoruri numerice cantitative, fiind astfel ideale pentru monitorizarea pacien\u021bilor \u0219i pentru studii clinic<\/p>\n
To\u021bi biomarkerii FibroTest sunt standardiza\u021bi, automatiza\u021bi \u0219i eficien\u021bi din punctul de vedere al costurilor, fiind u\u0219or de implementat pe platformele tehnice principale ale laboratoarelor medicale. BioPredictive propune algoritmi patenta\u021bi pentru calculul scorurilor leziunilor hepatice, care sunt aplica\u021bi on-line pe baza evalu\u0103rilor locale ale biomarkerilor, asigurate de analizoarele validate din laboratoare. Calculul on-line este efectuat de c\u0103tre medicul de laborator, iar foaia de rezultat se genereaz\u0103 instant. Un sistem expert analizeaz\u0103 fiecare FibroTest\/FibroMax \u0219i parametri s\u0103i pentru a se asigura aplicabilitatea corespunz\u0103toare.<\/p>\n
FibroTest este un test de prim\u0103 linie \u00een VHC \u0219i VHB, dovedindu-\u0219i robuste\u021bea \u00een practica clinic\u0103,fiind validat de asemenea pentru pacien\u021bii pediatrici \u0219i popula\u021biile speciale precum pacien\u021bii coinfecta\u021bi cu HIV, transplantan\u021bii hepatici, pacien\u021bii cu insuficien\u021b\u0103 renal\u0103 sau transplant renal, pacien\u021bii cu boal\u0103 cronic\u0103 inflamatorie, cei cu hemofilie, cu v\u00e2rste peste 65 de ani \u0219i copii. FibroMax este validat \u00een plus pentru boala alcoolic\u0103 hepatic\u0103 (steatoza \u0219i steatohepatita), steatoza \u0219i steatohepatita non-alcoolic\u0103 (diabet, exces ponderal, hipertrigliceridemie, hipercolesterolemie, hipertensiune arterial\u0103).<\/p>\n
Lansat \u00een 2002 \u00een Fran\u021ba, FibroTest este un test de prim\u0103 inten\u021bie, folosit din anul 2007 \u00een practica clinic\u0103 de rutin\u0103 a celor mai multe departamente de gastroenterologie \u0219i hepatologie (peste 80% dintre hepatologii francezi). FibroTest este recomandat de ghidurile EASL pentru hepatita cronic\u0103 cu virus C (VHC) din 2011 \u0219i pentru hepatita cronic\u0103 cu virus B (VHB) din 2012.<\/p>\n
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FibroTest\u00ae \u0219i FibroMax\u00ae sunt singurele teste hepatice serice, care m\u0103soar\u0103 toate leziunile hepatice (fibroza, activitatea inflamatorie, steatoza, NASH \u0219i ASH). \u00cen Rom\u00e2nia, \u00een protocoalele na\u021bionale, ca alternativ\u0103 la punc\u021bia biopsie […]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[257],"tags":[260,263,259,258,264,261,262],"class_list":["post-4351","post","type-post","status-publish","format-standard","category-medicina-interna","tag-biomarkerii-fibrotest","tag-biopredictive","tag-fibromax","tag-fibrotest","tag-noninvasive-ro","tag-virus-hepatic-b","tag-virus-hepatic-c"],"yoast_head":"\n
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<\/a><\/p>\n