{"id":5575,"date":"2016-04-12T11:49:40","date_gmt":"2016-04-12T11:49:40","guid":{"rendered":"https:\/\/jurmed.ro\/medici\/?p=5575"},"modified":"2016-04-12T11:49:40","modified_gmt":"2016-04-12T11:49:40","slug":"scaderea-rezistentei-la-insulina-in-nafld-cu-ajutorul-unui-hepatoprotector-natural-eficient","status":"publish","type":"post","link":"https:\/\/jurmed.ro\/medici\/scaderea-rezistentei-la-insulina-in-nafld-cu-ajutorul-unui-hepatoprotector-natural-eficient\/","title":{"rendered":"Sc\u0103derea rezisten\u0163ei la insulin\u0103 \u00een NAFLD cu ajutorul unui hepatoprotector natural eficient"},"content":{"rendered":"

\"DR_LuminitaAutor:
\nDr. Lumini\u021baParaschiv, <\/strong><\/p>\n

Product Manager,
\nPrisum – Himalaya<\/p>\n

Insulina joac\u0103 un rol important \u00een reglarea produc\u0163iei de glucoz\u0103 \u015fi \u00een metabolismul lipidic la nivel hepatic. \u00cen cazul ficatului gras sunt afecta\u0163i receptorii pentru insulin\u0103, afla\u0163i \u00een num\u0103r mare pe suprafa\u0163a ficatului, iar rezisten\u0163a la insulin\u0103 la nivel hepatic duce la agravarea hiperglicemiei \u015fi a hiperinsulinemiei. Rezisten\u0163a la insulin\u0103 la nivelul hepatocitelor atrage dup\u0103 sine reducerea glicogenului hepatic, \u00een timp ce produc\u0163ia hepatic\u0103 de glucoz\u0103 cre\u015fte, \u00een special pe calea gluconeogenezei.(1)<\/sup><\/strong>a nivel hepatic exist\u0103 o str\u00e2ns\u0103 leg\u0103tur\u0103 \u00eentre metabolismul glucidic \u015fi cel lipidic. O serie de studii au demonstrat interdependen\u0163a dintre rezisten\u0163a la insulin\u0103 \u015fi steatoza metabolic\u0103, \u00een sensul c\u0103 rezisten\u0163a la insulin\u0103 conduce la steatoz\u0103 hepatic\u0103, iar steatoza hepatic\u0103 agraveaz\u0103 rezisten\u0163a la insulin\u0103, prin implicarea unor mecanisme extra sau intrahepatice.(1)<\/sup><\/strong><\/p>\n

Ameliorarea NAFLD, sc\u0103derea gr\u0103simii din hepatocite \u015fi \u00eembun\u0103t\u0103\u0163irea func\u0163ionalit\u0103\u0163ii hepatice determin\u0103 cre\u015fterea sensibilit\u0103\u0163ii receptorilor pentru insulin\u0103, \u00eembun\u0103t\u0103\u0163irea glicogenogenezei \u015fi sc\u0103derea produc\u0163iei de glucoz\u0103 la nivel hepatic.<\/p>\n

Un hepatoprotector eficient sus\u0163ine func\u0163ionalitatea ficatului \u00een totalitate, determin\u00e2nd \u00eembun\u0103t\u0103\u0163irea mai multor parametri.<\/p>\n

Liv.52<\/strong> este recunoscut pentru rolul s\u0103u \u00een prevenirea \u015fi combaterea bolii ficatului gras nonalcoolic. Plantele din compozi\u0163ie \u00eembun\u0103t\u0103\u0163esc metabolismul lipidic, combat stresul oxidativ prin aportul bogat de antioxidan\u0163i, au rol antiinflamator \u015fi previn instalarea NASH, inhib\u0103 fibrogeneza \u015fi trecerea spre ciroz\u0103. Studiile realizate de-a lungul timpului au ar\u0103tat c\u0103 utilizarea produsului Liv.52<\/strong> \u00een NAFLD determin\u0103 sc\u0103derea semnificativ\u0103 a enzimelor hepatice, precum \u015fi reducerea nivelului colesterolului \u015fi al trigliceridelor din s\u00e2nge. Mai nou, s-a monitorizat \u015fi influen\u0163a manifestat\u0103 de Liv.52<\/strong> asupra sc\u0103derii rezisten\u0163ei la insulin\u0103 \u00een NAFLD.<\/p>\n

\u00centr-un studiu experimental publicat anul trecut s-a dovedit c\u0103 Liv.52<\/strong> intervine \u00een NASH \u015fi prin sc\u0103derea rezisten\u0163ei la insulin\u0103, asem\u0103n\u0103tor pioglitazonei, cunoscut\u0103 ca sensibilizator al receptorilor pentru insulin\u0103. \u00cen grupurile care au primit Liv.52<\/strong> \u015fi pioglitazon\u0103 s-au \u00eenregistrat reducerea GPT, GOT, ALP, a colesterolului \u015fi a trigliceridelor, dar \u015fi sc\u0103derea rezisten\u0163ei la insulin\u0103, reducerea glicemiei \u00e0 jeun \u015fi a insulinemiei, respectiv \u00eembun\u0103t\u0103\u0163irea indexului HOMA.(2)<\/sup><\/strong>
\n\"Flyer<\/sup><\/strong><\/p>\n

Cre\u015fterea capacit\u0103\u0163ii de captare a glucozei de c\u0103tre ficatul gras nonalcoolic \u00een cazul administr\u0103rii Liv.52<\/strong>, comparativ cu silimarina \u015fi vitamina E, a fost demonstrat\u0103 \u015fi \u00eentr-un studiu \u00een vitro. Celulele hepatice folosite \u00een studiu, provenite din linia HepG2, au fost men\u0163inute \u00een mediu normal (control) sau \u00een medii \u00een care s-a ad\u0103ugat acid oleic pentru inducerea steatozei hepatice. Rezultatele au ar\u0103tat c\u0103 Liv.52<\/strong> reduce \u00eenc\u0103rcarea cu gr\u0103sime a ficatului, cre\u015fte nivelul antioxidan\u0163ilor, reduce citokinele proinflamatorii \u015fi cre\u015fte capacitatea de captare a glucozei mai eficient dec\u00e2t silimarina sau vitamina E.(3)<\/sup><\/strong><\/p>\n

\"image
image description<\/figcaption><\/figure>\n

\u00cembun\u0103t\u0103\u0163irea metabolismului glucidic \u015fi lipid la nivel hepatic, ameliorarea dislipidemiei \u015fi sc\u0103derea rezisten\u0163ei la insulin\u0103 reprezint\u0103 motive \u00een plus pentru utilizarea Liv.52<\/strong> \u00een toate stadiile NAFLD.<\/p>\n

Bibliografie:<\/p>\n

    \n
  1. \n
    \u201cInsulin resistance and steatosis \u00een humans\u201d- J. Capeau-H\u00f4pital Tenon, 75020 Paris, France, Diabetes <\/strong>\u2018Diabetes & Metabolism (2008)<\/em><\/h6>\n<\/li>\n
  2. \n
    \u201cExtract of a polyherbal formulation ameliorates experimental nonalcoholic steatohepatitis\u201d – M. Azeemuddin , M. Rafiq, S. D. Anturlikar, L. Kumar, P. Patki, U. Babu , R. Shyam, <\/strong>Journal of Traditional and Complementary Medicine (2015)<\/em><\/h6>\n<\/li>\n<\/ol>\n
    3.\u201cLiv.52 up-regulates cellular antioxidants and increase glucose uptake to circumvent oleic acid induced hepatic steatosis \u00een HepG2 cells\u201d \u2013 S. Vidyashankara,*, L.M. Sharath Kumarb, V. Barooaha, R. Sandeep Varmaa, K. S. Nandakumara, P. Patkic <\/strong>Phytomedicine (2012)<\/em><\/h6>\n","protected":false},"excerpt":{"rendered":"

    Autor: Dr. Lumini\u021baParaschiv, Product Manager, Prisum – Himalaya Insulina joac\u0103 un rol important \u00een reglarea produc\u0163iei de glucoz\u0103 \u015fi \u00een metabolismul lipidic la nivel hepatic. \u00cen cazul ficatului gras sunt […]<\/p>\n","protected":false},"author":5,"featured_media":5508,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[33,282,1],"tags":[517,518,426,161],"class_list":["post-5575","post","type-post","status-publish","format-standard","has-post-thumbnail","category-articole","category-diabet","category-stiri-noutati","tag-ficat-gras","tag-hepatic","tag-himalaya","tag-liv-52"],"yoast_head":"\nSc\u0103derea rezisten\u0163ei la insulin\u0103 \u00een NAFLD cu ajutorul unui hepatoprotector natural eficient - Jurmed - Medici<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jurmed.ro\/medici\/scaderea-rezistentei-la-insulina-in-nafld-cu-ajutorul-unui-hepatoprotector-natural-eficient\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sc\u0103derea rezisten\u0163ei la insulin\u0103 \u00een NAFLD cu ajutorul unui hepatoprotector natural eficient - 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