{"id":6111,"date":"2016-10-10T09:38:09","date_gmt":"2016-10-10T09:38:09","guid":{"rendered":"https:\/\/jurmed.ro\/medici\/?p=6111"},"modified":"2016-10-10T09:38:09","modified_gmt":"2016-10-10T09:38:09","slug":"harpagophytum-procumbens-alternativa-naturala-terapia-durerilor-articulare","status":"publish","type":"post","link":"https:\/\/jurmed.ro\/medici\/harpagophytum-procumbens-alternativa-naturala-terapia-durerilor-articulare\/","title":{"rendered":"Harpagophytum procumbens – alternativa natural\u0103 \u00een terapia durerilor articulare"},"content":{"rendered":"

Harpagophytum procumbens – descriere<\/strong><\/span><\/p>\n

Harpagophytum procumbens(HP), plant\u0103 numit\u0103 popular Gheara-diavolului,\u00a0 face parte din familia Pedaliaceae. Provine din partea sudic\u0103 a continentului african \u0219i poate fi gasit\u0103nativ pe \u00eentinderea de\u0219ertului Kalahari din Namibia, a Botswanei, Africii de Sud, Angolei, Zambiei \u0219i Zimbabwe. Gheara-diavolului este o plant\u0103 peren\u0103 ierboas\u0103, cu o lungime de aproximativ 45 cm, cu o r\u0103d\u0103cin\u0103 pivotant\u0103 central\u0103 robust\u0103, care se \u00eentinde p\u00e2n\u0103 la o ad\u00e2ncime de doi metri.Florile au form\u0103 de trompet\u0103\u0219i sunt roz, ro\u0219ii sau mov, cu un mijloc g\u0103lbui. Fructul este lemnos \u0219i r\u0103sp\u00e2nde\u0219te numero\u0219i ghimpi lungi; datorit\u0103 formei acestor ghimpi, fructul este cel care d\u0103 binecunoscutul nume al plantei.<\/p>\n

Harpagophytum procumbens – istoric<\/strong><\/span><\/p>\n

Mai multe surse arat\u0103 c\u0103, la jum\u0103tatea secolului XIX, elve\u021bianul Augustin-Pyrame de Candolle a fost primul botanist care a descris \u0219i a consemnat existen\u021ba HP, de\u0219i se pare c\u0103, la momentul respectiv, nu se cuno\u0219teau cu exactitate propriet\u0103\u021bile medicinale ale plantei. \u00cen medicina popular\u0103 european\u0103,Gheara-diavolului este folosit\u0103\u00eenc\u0103 de la jum\u0103tatea secolului trecut, \u00een principal \u00een tratamentul afec\u021biunilor reumatice. Monografia curent\u0103 a ESCOP (European Scientific Cooperative on Phytotherapy) recomand\u0103 preparatele de Gheara-diavolului la tratamentul simptomatic al artrozei dureroase, al durerilor de spate, al lipsei de poft\u0103 de m\u00e2ncare \u0219i al dispepsiei.<\/p>\n

<\/h3>\n

Harpagophytum procumbens<\/em><\/strong> – componente principale<\/strong><\/span><\/p>\n

Componentele principale ale tuberculilor secundari de Gheara-diavolului sunt glicozidele iridoide, care reprezint\u0103 aproximativ 3%. Ingredientul principal al acestora sunt harpagozidele, urmat\u0103 de procumbid\u0103, harpagid\u0103 \u0219i 8-para-cumaroil-harpagid\u0103. Al\u021bi compu\u0219i importan\u021bi sunt flavonele, cum sunt kempferolul \u0219i luteolina, derivatele de 2-feniletanol, cum este acteozida, \u0219i substan\u021bele hidrosolubile, cum sunt stachioza, rafinoza \u0219i produ\u0219ii lor de descompunere.<\/p>\n

Mai multe studii experimentale au evaluat activitatea analgezic\u0103, anti-inflamatorie, anti-edematoas\u0103 \u0219i anti-artritic\u0103; majoritatea acestora au identificat niveluri de activitate medii p\u00e2n\u0103 la ridicate.<\/p>\n

Harpagophytum procumbens<\/em><\/strong> – mecanisme de ac\u021biune<\/strong><\/span><\/p>\n

Antiinflamator<\/strong> – un studiu in vitro, folosind dou\u0103 linii celulare la \u0219obolani, a constatat c\u0103 harpagozidele inhib\u0103 oxidul nitric inductiv indus cu lipopolizaharide (iNOS) \u0219i expresia ciclooxigenaz\u0103-2 (COX-2) prin suprimarea factorului nuclear kappaB (NF-\u03baB), astfel inhib\u00e2nd inflama\u021bia.<\/p>\n

Analgezic<\/strong> – se pare ca harpagozidele exercit\u0103 un efect analgezic periferic. Studiile in vivo (umane) au demonstrat dureri diminuate \u00een cazurile de gonartroz\u0103, coxartroz\u0103\u0219i durerilombare, dup\u0103 ingerarea de extracte de Gheara-diavolului con\u021bin\u00e2nd harpagozide.Mecanismul care sus\u021bine acest efect este \u00een str\u00e2ns\u0103 leg\u0103tur\u0103 cu propriet\u0103\u021bile sale anti-inflamatorii.<\/p>\n

Harpagophytum procumbens<\/em><\/strong> – eficacitate<\/strong><\/span><\/p>\n

Studiile au constatat c\u0103 HP prezint\u0103 o bun\u0103 activitate analgezic\u0103 \u0219i anti-inflamatorie \u00een tratamentul pacien\u021bilor cu simptome u\u0219oare p\u00e2n\u0103 la intermediare \u00een coxartroz\u0103 sau gonartroz\u0103\u0219i dureri lombare. Un astfel de exemplu este studiul desf\u0103\u0219urat asupra a 65 de pacien\u021bi cu dureri u\u0219oare p\u00e2n\u0103 la intermediare (pe scala VAS) sau cu tensiune muscular\u0103 \u00een umeri, ceaf\u0103 \u0219i\/sau spate. Dup\u0103 4 s\u0103pt\u0103m\u00e2ni de tratament cu placebo sau 2x480mg extract de HP (cu 3% harpagozide) s-a remarcat o \u00eembun\u0103t\u0103\u021bire semnificativ\u0103 a durerii musculare \u00een cadrul grupului de tratament activ fa\u021b\u0103 de placebo (p<0,001) \u0219i o diminuare considerabil\u0103 a rigidit\u0103\u021bii (p<0,001).<\/p>\n

\"grafic\"<\/a><\/p>\n

\n

Intensitatea durerii musculare (0-50) dup\u0103 4 s\u0103pt\u0103m\u00e2ni de 2x480mg Harpagophytum sau placebo<\/em><\/p>\n

\u00centr-un alt studiu multicentric, controlat, s-au administrat 2400 mg extract apos de tuberculi de Gheara-diavolului, echivalent cu 50mg harpagozide zilnic, la 75 de pacien\u021bi cu coxartroz\u0103\u0219i gonartroz\u0103, timp de 12 s\u0103pt\u0103m\u00e2ni. Durerea a fost evaluat\u0103 prin chestionarul Universit\u0103\u021bilor Western Ontario \u0219i McMaster (WOMAC), o scal\u0103 analog vizual\u0103 (VAS) \u0219i examinare de c\u0103tre medic \u00een momentul de referin\u021b\u0103, la \u0219ase \u0219i la 12 s\u0103pt\u0103m\u00e2ni. La 12 s\u0103pt\u0103m\u00e2ni, scorul total WOMAC al durerii a fost diminuat cu 24,5% fa\u021b\u0103 de punctul de referin\u021b\u0103. Evaluarea fizica a durerii a prezentat o ameliorare de 46% a durerii la palpare, ameliorare de 35% a limitarii mobilit\u0103tii \u0219i o ameliorare de 25,4% a crepita\u021biei articulare la 12 s\u0103pt\u0103m\u00e2ni.<\/p>\n

Harpagophytum procumbens<\/em><\/strong> – administrare<\/strong><\/span><\/p>\n

Comparate cu AIS, preparatele de Gheara-diavolului ac\u021bioneaz\u0103 lent. Prin urmare, trebuie administrate timp de 2-4 s\u0103pt\u0103m\u00e2nipentru a ob\u021bine rezultate stabile \u00een timp. Dac\u0103 preparatele de Gheara-diavolului sunt administrate ca terapie de baz\u0103, de obicei pacientul poate diminua doza de analgezice sintetice \u0219i, astfel, mic\u0219ora riscul de efecte secundare gastrointestinale. Dac\u0103 pacientul r\u0103spunde rapid la tratamentul cu HP, terapia poate fi administrat\u0103 timp \u00eendelungat f\u0103r\u0103 riscuri\u0219i se poate renun\u021ba la antiinflamatoarele de sintez\u0103. Nu s-au constatat interac\u021biuni cu alte medicamente.<\/p>\n

Harpagophytum procumbens<\/em><\/strong> – toleran\u021b\u0103<\/strong><\/span><\/p>\n

Efectele secundare sunt pu\u021bine \u0219i restr\u00e2nse, de obicei, la tulbur\u0103ri gastrointestinale. \u00centr-o analiz\u0103 a 28 de studii clinice asupra extractelor de Gheara-diavolului, efectele secundare s-au manifestat la aproximativ 3% din pacien\u021bi \u0219i nu au dep\u0103\u0219it cota celor \u00eencercate cu placebo. Utilizarea pe termen lung este sigur\u0103 \u0219i nu prezint\u0103 toxicitate.Toate studiile clinice efectuate cu Gheara-diavolului \u00een durerile articulare sau musculare au constatat o tolerabilitate foarte bun\u0103, chiar \u0219i\u00een cazul administr\u0103rii pe termen lung.<\/p>\n

Bibliografie:<\/h6>\n
    \n
  • \n
    Whitehouse LW, Znamirowska M, Paul CJ. Devil\u2019s claw (Harpagophytum procumbens<\/em>): no evidence for anti-inflammatory activity \u00een the treatment ofarthritic disease. Can Med Assoc J 1983;129:249-251.<\/h6>\n<\/li>\n
  • \n
    Vlachojannis J, Roufogalis BD, Chrubasik S. Systematic review on the safety of Harpagophytum preparations for osteoarthritic and low back pain. Phytother Res 2008;22:149-152.<\/h6>\n<\/li>\n
  • \n
    Wegener T. Die Teufelskralle (Harpagophytum procumbens DC<\/em>) \u00een der Therapie rheumatischer Erkrankungen. Zeitschrift f\u00fcr Phytotherapie 1998;19:284-294.<\/h6>\n<\/li>\n
  • \n
    Holz W et al. Harpagophyti radix. \u00cen: H\u00e4nsel R et al. Hagers Handbuch der Pharmazeutischen Praxis, 5. Auflage, Band 5, Drogen E-O. Springer Verlag, Berlin 1993:485-490.<\/h6>\n<\/li>\n
  • \n
    ESCOP – Monografie: Harpagophyti radix. 2003, p. 233-240.<\/h6>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    Harpagophytum procumbens – descriere Harpagophytum procumbens(HP), plant\u0103 numit\u0103 popular Gheara-diavolului,\u00a0 face parte din familia Pedaliaceae. Provine din partea sudic\u0103 a continentului african \u0219i poate fi gasit\u0103nativ pe \u00eentinderea de\u0219ertului Kalahari […]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[363],"tags":[],"class_list":["post-6111","post","type-post","status-publish","format-standard","category-reabilitare-medicala"],"yoast_head":"\nHarpagophytum procumbens - alternativa natural\u0103 \u00een terapia durerilor articulare - Jurmed - Medici<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jurmed.ro\/medici\/harpagophytum-procumbens-alternativa-naturala-terapia-durerilor-articulare\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Harpagophytum procumbens - alternativa natural\u0103 \u00een terapia durerilor articulare - Jurmed - Medici\" \/>\n<meta property=\"og:description\" content=\"Harpagophytum procumbens – descriere Harpagophytum procumbens(HP), plant\u0103 numit\u0103 popular Gheara-diavolului,\u00a0 face parte din familia Pedaliaceae. 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