{"id":7633,"date":"2018-01-19T14:09:03","date_gmt":"2018-01-19T14:09:03","guid":{"rendered":"https:\/\/jurmed.ro\/medici\/?p=7633"},"modified":"2018-01-19T14:09:03","modified_gmt":"2018-01-19T14:09:03","slug":"rolul-factorilor-neurotrofici-dementa-alzheimer","status":"publish","type":"post","link":"https:\/\/jurmed.ro\/medici\/rolul-factorilor-neurotrofici-dementa-alzheimer\/","title":{"rendered":"Rolul factorilor neurotrofici \u00een demen\u021ba Alzheimer"},"content":{"rendered":"

Datele epidemiologice obiectiveaz\u0103 o cre\u015ftere\u00a0semnificativ\u0103 a inciden\u0163ei cazurilor de boal\u0103 Alzheimer\u00a0\u00een direct\u0103 rela\u0163ie cu \u00eemb\u0103tr\u00e2nirea popula\u0163iei.\u00a0Mijloacele de investigare au permis eviden\u0163ierea
\nunor indicatori neurobiologici de predic\u0163ie a deterior\u0103rii\u00a0cognitive \u00eenc\u0103 din stadiile incipiente de\u00a0boal\u0103, precum \u015fi eviden\u0163ierea unor factori de risc\u00a0ce pot favoriza progresia rapid\u0103 a fenomenelor de
\ntip deteriorativ-cognitiv.<\/p>\n

Strategiile terapeutice se bazeaz\u0103 pe augmentarea transmisiei\u00a0colinergice \u0219i pe modelarea transmisiei glutamatergice,\u00a0ipotezele etiopatogenice validate de psihofarmacologia\u00a0demen\u021bei Alzheimer centr\u00e2ndu-se pe deficitul transmisiei acetilcolinice\u00a0\u0219i hiperactivitatea receptorilor de tip NMDA.<\/p>\n

Cercetarea fundamental\u0103 a scos \u00een eviden\u021b\u0103 faptul c\u0103 patogenia\u00a0acestei afec\u021biuni este multifactorial\u0103, fiind decelate mai multe\u00a0niveluri de vulnerabilitate, principalele fiind vulnerabilitatea
\ngenetic\u0103, biologico-biochimic\u0103 \u0219i vulnerabilitatea raportului neuronastroglie \u00een func\u021bionalitatea unit\u0103\u021bii neuroanatomice a creierului,\u00a0unitatea neurovascular\u0103.
\nRolul factorului vascular scotomizat de excesivitatea\u00a0explica\u021biilor neurodegenerative are o importan\u021b\u0103 major\u0103, fiind un\u00a0veritabil conglomerat multifactorial ce implic\u0103 func\u021bia endotelial\u0103,
\nprocesele proinflamatorii, mecanisme citokinice \u0219i agresiuni\u00a0autodistructive de tip excitotoxic sau apoptotic.<\/p>\n

Perspectiva actual\u0103 urm\u0103re\u0219te conservarea raportului neuronastroglie\u00a0prin influen\u021barea multisistemic\u0103 a condi\u021biilor patogenice\u00a0multiple discut\u00e2ndu-se de veritabili factori neuroprotectivi
\nce pot \u00eent\u00e2rzia semnificativ evolu\u021bia deteriorativ-cognitiv\u0103 \u00een\u00a0contrast cu factorii disprotectivi ce precipit\u0103 aceast\u0103 deteriorare.<\/p>\n

Principalii factori neuroprotectivi sunt reprezenta\u021bi de factorii\u00a0neurotrofici.Identificarea factorilor de risc sau a celor de precipitare,\u00a0trecerea rapid\u0103 de la stadiul MCI spre stadiile avansate ale
\ndeterior\u0103rii cognitive \u0219i utilizarea \u00een scop terapeutic a factorilor\u00a0neurotrofici permit \u00eent\u00e2rzierea evolu\u021biei. Ac\u021biunea factorilor neurotrofici\u00a0este exercitat\u0103 la nivel celular \u0219i molecular, \u00eentrerup\u00e2nd
\ncascadele patogenice neurodegenrative.<\/p>\n

Influen\u021ba exercitat\u0103 de factorii neuroprotectivi asigur\u0103 conservarea\u00a0transmisiei de tip colinergic, cu un veritabil scut de\u00a0protec\u021bie la nivel sinaptic \u00eempotriva agresiunii de tip beta-amiliod,
\nscad neuroinflama\u021bia, modeleaz\u0103 endoteliul vascular la nivel\u00a0cerebral dar \u0219i la nivel cardiac, fapt ce permite o men\u021binere constant\u0103\u00a0a nivelului de perfuzie vascularo-metabolic\u0103 \u00een unitatea
\nneurofunc\u021bional\u0103 cerebral\u0103.Beneficiile strategiilor terapeutice bazate pe factorii neurotrofici\u00a0sunt sus\u021binute at\u00e2t de cercet\u0103rile pe model animal, \u00een\u00a0condi\u021biile de hipoperfuzie vascular\u0103 cerebral\u0103 controlat\u0103, c\u00e2t \u0219i\u00a0de studii de tip meta-analiz\u0103 efectuate recent. Utilizarea preparatelor\u00a0de tip Cerebrolysin \u00een condi\u021biile identific\u0103rii momentelor\u00a0disprotective poate \u00eembun\u0103t\u0103\u021bi semnificativ evolu\u021bia bolii \u0219i calitatea\u00a0vie\u021bii pacien\u021bilor \u0219i apar\u021bin\u0103torilor acestora.<\/p>\n

Cuvinte cheie: raport neuron-astroglie, factori neurotrofici,momente disprotective.<\/p>\n","protected":false},"excerpt":{"rendered":"

Datele epidemiologice obiectiveaz\u0103 o cre\u015ftere\u00a0semnificativ\u0103 a inciden\u0163ei cazurilor de boal\u0103 Alzheimer\u00a0\u00een direct\u0103 rela\u0163ie cu \u00eemb\u0103tr\u00e2nirea popula\u0163iei.\u00a0Mijloacele de investigare au permis eviden\u0163ierea unor indicatori neurobiologici de predic\u0163ie a deterior\u0103rii\u00a0cognitive \u00eenc\u0103 din […]<\/p>\n","protected":false},"author":4,"featured_media":7634,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[77],"tags":[],"class_list":["post-7633","post","type-post","status-publish","format-standard","has-post-thumbnail","category-psihiatrie"],"yoast_head":"\nRolul factorilor neurotrofici \u00een demen\u021ba Alzheimer<\/title>\n<meta name=\"description\" content=\"Rolul factorilor neurotrofici \u00een demen\u021ba Alzheimer\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jurmed.ro\/medici\/rolul-factorilor-neurotrofici-dementa-alzheimer\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rolul factorilor neurotrofici \u00een demen\u021ba Alzheimer\" \/>\n<meta property=\"og:description\" content=\"Rolul factorilor neurotrofici \u00een demen\u021ba Alzheimer\" \/>\n<meta property=\"og:url\" content=\"https:\/\/jurmed.ro\/medici\/rolul-factorilor-neurotrofici-dementa-alzheimer\/\" \/>\n<meta property=\"og:site_name\" content=\"Jurmed - 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