{"id":9094,"date":"2019-09-13T07:27:12","date_gmt":"2019-09-13T07:27:12","guid":{"rendered":"https:\/\/jurmed.ro\/medici\/?p=9094"},"modified":"2019-09-13T08:09:58","modified_gmt":"2019-09-13T08:09:58","slug":"9094-2","status":"publish","type":"post","link":"https:\/\/jurmed.ro\/medici\/9094-2\/","title":{"rendered":"Care sunt cele mai noi tratamente \u0219i terapii \u00eempotriva migrenelor?"},"content":{"rendered":"

\"\"<\/strong><\/p>\n

Articol realizat de dr. Bogdan Pan\u0103, corespondent de la Congresul Societ\u0103\u021bii Interna\u021bionale a Cefaleei de la Dublin (5-8 septembrie)<\/strong><\/p>\n

De\u0219i nu este cea mai frecvent\u0103 form\u0103 de cefalee (durere de cap), migrena este vedeta Congresului Societ\u0103\u021bii Interna\u021bionale a Cefaleei, desf\u0103\u0219urat la Dublin \u00eentre 5 \u0219i 8 septembrie, fiind tema central\u0103 \u00een 3 din 4 comunicari orale \u0219i 2 din 3 postere expuse. Acest lucru se datoreaz\u0103 faptului c\u0103 migrena este prima cauz\u0103 de dizabilitate la persoane cu v\u00e2rsta de sub 50 de ani, reprezent\u00e2nd, pe l\u00e2ng\u0103 o dram\u0103 personal\u0103 a pacientului \u0219i a familiei acestuia, o problem\u0103 cu implica\u021bii majore socio-economice (neproductivitate, lipsa de la locul de munc\u0103 etc).<\/p>\n

Av\u00e2nd \u00een vedere aceste implica\u021bii, aproximativ 90% din fondurile destinate cercet\u0103rii cefaleelor sunt direc\u021bionate c\u0103tre migren\u0103. Prin urmare, \u00een ultimul an au ap\u0103rut primele terapii \u021bintite \u00een tratarea acesteia. Tratamentul migrenei se \u00eemparte \u00een dou\u0103 categorii: \u00een acut (atunci c\u00e2nd doare capul) \u0219i profilactic (de preven\u021bie, recomandat persoanelor care au mai mult de 4 atacuri pe lun\u0103, sau atunci c\u00e2nd atacurile sunt de lung\u0103 durat\u0103). Noile terapii de tratare a migrenei au ap\u0103rut pentru a completa anumite nevoi ne\u00eendeplinite de medica\u0163ia existent\u0103 la momentul actual. \u00cen acut, tratamentul medicamentos este ineficient \u00een 25% din cazuri iar mul\u0163i pacien\u021bi nu pot suporta efectele adverse sau au contraindica\u0163ie \u00een a le administra.<\/p>\n

P\u00e2n\u0103 acum, tratamentul profilactic al migrenei era reprezentat de medicamente antiepileptice, antidepresive sau betablocante. Acestea erau ineficiente \u00een jum\u0103tate din cazuri, iar \u00eempreun\u0103 cu efectele adverse conduceau la o aderen\u021b\u0103 sc\u0103zut\u0103 la tratament, jum\u0103tate dintre pacien\u021bi urm\u00e2ndu-l pentru 2 luni \u0219i mai putin de 20% pentru un an \u00eentreg.<\/p>\n

Ce sunt anticorpii monoclonali anti CGRP?<\/strong><\/p>\n

\"\"<\/a>Moleculele CGRP (Calcitonin Gene Related Peptide) sunt neuropeptide descoperite \u00eenca de acum 35 de ani. \u00cen ultimii 15 ani s-a studiat \u0219i dovedit efectul vasodilatator al acestora \u0219i rolul lor \u00een declan\u0219area \u0219i \u00eentre\u021binerea migrenei.<\/p>\n

\u00cen 2018 a fost aprobat FDA primul anticorp monoclonal eficient \u00een tratarea profilactic\u0103 a migrenei, Erenumab. Acesta blocheaz\u0103 receptorul de care se ata\u0219eaz\u0103 moleculele de CGRP, \u00eempiedic\u00e2ndu-le astfel s\u0103 \u00ee\u0219i produc\u0103 efectele. Ulterior au fost aproba\u021bi al\u021bi anticorpi monoclonali, Eptinezumab, Fremanezumab \u0219i Galcanezumab, care se ata\u0219eaz\u0103 direct de moleculele CGRP. Erenumab se administreaz\u0103 printr-o injec\u021bie subcutanat\u0103, o dat\u0103 pe lun\u0103.<\/p>\n

Aprobarea s-a bazat pe rezultatele a dou\u0103 studii care au inclus 667 de pacien\u021bi cu migren\u0103 cronic\u0103 \u0219i 955 cu migren\u0103 episodic\u0103. Dup\u0103 trei luni de tratament s-a observat o sc\u0103dere de 3.2 sau 3.7 zile pe lun\u0103 pentru pacien\u021bii cu migren\u0103 episodic\u0103, \u00een func\u021bie de doz\u0103. Din p\u0103cate, av\u00e2nd \u00een vedere costurile mari de producere a acestor anticorpi, costul anual pentru un tratament este de c\u00e2teva mii de euro. \u00cen multe \u021b\u0103ri europene se ia \u00een considerare acoperirea acestor costuri de c\u0103tre casele de asigur\u0103ri. Dac\u0103 pentru pacien\u021bii din Rom\u00e2nia accesul la terapie nu este \u00eenc\u0103 posibil, iar aceste costuri pot fi extrem de prohibitive, exist\u0103 solu\u021bii inovative \u0219i pentru ei.<\/p>\n

Cu costuri de peste 10 ori mai mici, neuromodularea prin stimulare electric\u0103 transcutanat\u0103 a nervului trigemen, cu Cefaly Dual, primul dispozitiv de neurostimulare aprobat FDA pentru tratarea migrenei \u00een acut \u0219i \u00een preven\u021bie, ap\u0103rut \u00een Europa \u00een septembrie 2018. Acesta stimuleaz\u0103 ramura supraorbital\u0103 a nervului trigemen prin aplicarea pe frunte a unui plasture autoadeziv, de care dispozitivul se ata\u0219eaz\u0103 magnetic.\u00a0 Este u\u0219or de utilizat, iar \u00een timpul folosirii pacientul \u00ee\u0219i poate desf\u0103\u0219ura activit\u0103\u0163ile obi\u0219nuite. Acesta are dou\u0103 set\u0103ri: tratament \u00een acut (o or\u0103)\u00a0 \u0219i preventiv (zilnic, 20 de minute).<\/p>\n

Ce este neuromodularea?<\/strong><\/p>\n

Neuromodularea este o tehnic\u0103 prin care se poate ac\u0163iona electric sau chimic, cat mai \u0163intit posibil la nivelul sistemului nervos central sau periferic, \u00een scopul influen\u0163\u0103rii activit\u0103\u0163ii acestora. Epoca modern\u0103 a neuromodul\u0103rii a \u00eenceput \u00een anii 1960 odat\u0103 cu utilizarea DBS (deep brain stimulation) pentru tratarea \"\"<\/a>durerii cronice. \u00cen prezent, neuromodularea (invaziv\u0103 sau non-invaziv\u0103) este indicat\u0103 \u00een tulbur\u0103ri de mi\u0219care, epilepsie, reabilitare medical\u0103 sau psihiatrie. \u00cenc\u0103 din Antichitate, medicul-\ufb01lozof Galen folosea pe\u0219ti electrici pentru a ameliora simptomele pacientilor s\u0103i ce acuzau dureri de cap.<\/p>\n

\"\"<\/p>\n

Dr. Bogdan Pan\u0103<\/strong>, medic neurolog la Centrul Medical Emerald, a prezentat la congresul de la Dublin rezultatele cercet\u0103rii f\u0103cute pe primii 39 de pacien\u021bi care au beneficiat de terapia Head’s UP prin Cefaly Dual din Rom\u00e2nia. Posterul a fost prezentat pe 7 septembrie \u0219i a fost realizat al\u0103turi de dr. Andra Iosif \u0219i dr. Adina Roceanu.<\/strong><\/p>\n

Ce a g\u0103sit studiul la pacien\u021bii cu migren\u0103 din Rom\u00e2nia?<\/strong><\/p>\n

Din totalul de 39 pacien\u021bi, dintre care 32 au putut fi inclu\u0219i \u00een studiu, 30 au fost femei \u0219i 2 b\u0103rba\u021bi. 2 dintre pacienti au renun\u021bat la terapie din primele zile, din cauza durerii din timpul sesiunilor si unul din cauza alergiei la acrilatul electrozilor. 9 pacien\u021bi au completat jurnalul migrenei zilnic, toti fiind de sex feminin. 5\/9 pacien\u021bi au raportat \u00een primele trei luni o sc\u0103dere semnificativ\u0103 a num\u0103rului de ore de durere cauzat\u0103 de migren\u0103 (cu peste 50% din durata anterioara), urm\u00e2nd ca \u00eenc\u0103 3 s\u0103 devin\u0103 responsivi dup\u0103 5 respectiv 7 luni de folosire a dispozitivului Cefaly Dual. Unul dintre ei, \u00een a 6 lun\u0103 de utilizare a devenit super-responsiv, adic\u0103 nu a mai avut nicio or\u0103 de durere (100% tratare a migrenei).<\/p>\n

\"\"<\/a>
Rezultate pacienti anonimizati<\/figcaption><\/figure>\n

La nivelul intensit\u0103\u021bii, la trei luni de utilizare, 22% dintre pacien\u021bi au experimentat o sc\u0103dere semnificativ\u0103 a durerii \u00een timpul atacurilor, 11% la patru luni de utilizare \u0219i al\u021bi 22% la \u0219apte luni de utilizare. Rezultatele sunt promi\u021b\u0103toare, situ\u00e2ndu-se peste rezultatele studiilor clinice efectuate \u00een Statele Unite si alte tari europene, acest fapt dator\u00e2ndu-se criteriilor foarte stricte de includere a pacien\u021bilor \u00een terapie, fiind recomandat\u0103 doar pacien\u021bilor care puteau cu adev\u0103rat fi ajuta\u021bi de acest dispozitiv inovativ.<\/p>\n

Pe l\u00e2ng\u0103 neuromodulare \u0219i anticorpi monoclonali, au fost prezentate o serie de noi terapii, aflate \u00een studii clinice momentan, cum ar fi impactul dietei keto sau terapia cu canabidiol, o substan\u021b\u0103 ce se reg\u0103se\u0219te \u00een canabis. Cu toate c\u0103 nu are efecte halucinogene \u0219i este folosit deja \u00een anumite state din SUA pentru tratarea altor afec\u021biuni (spasticitatea pacien\u021bilor cu scleroz\u0103 multipl\u0103 sau glaucom), utilizarea \u0219i studiile cu acest compus sunt dificile din cauza legisla\u021biei ambigue.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Articol realizat de dr. Bogdan Pan\u0103, corespondent de la Congresul Societ\u0103\u021bii Interna\u021bionale a Cefaleei de la Dublin (5-8 septembrie) De\u0219i nu este cea mai frecvent\u0103 form\u0103 de cefalee (durere de […]<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[81,1],"tags":[],"class_list":["post-9094","post","type-post","status-publish","format-standard","category-cardiologie","category-stiri-noutati"],"yoast_head":"\nAnticorpi monoclonali, noutatea congresului<\/title>\n<meta name=\"description\" content=\"De\u0219i nu este cea mai frecvent\u0103 form\u0103 de cefalee, migrena este vedeta Congresului Societ\u0103\u021bii Interna\u021bionale a Cefaleei, desf\u0103\u0219urat la Dublin \u00eentre 5 \u0219i 8 septembrie.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jurmed.ro\/medici\/9094-2\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Anticorpi monoclonali, noutatea congresului\" \/>\n<meta property=\"og:description\" content=\"De\u0219i nu este cea mai frecvent\u0103 form\u0103 de cefalee, migrena este vedeta Congresului Societ\u0103\u021bii Interna\u021bionale a Cefaleei, desf\u0103\u0219urat la Dublin \u00eentre 5 \u0219i 8 septembrie.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/jurmed.ro\/medici\/9094-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Jurmed - Medici\" \/>\n<meta property=\"article:published_time\" content=\"2019-09-13T07:27:12+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-09-13T08:09:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/jurmed.ro\/medici\/wp-content\/uploads\/sites\/2\/2019\/09\/DR-BOGDAN-PANA.jpg\" \/>\n<meta name=\"author\" content=\"Alina\" \/>\n<meta name=\"twitter:label1\" content=\"Scris de\" \/>\n\t<meta name=\"twitter:data1\" content=\"Alina\" \/>\n\t<meta name=\"twitter:label2\" content=\"Timp estimat pentru citire\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/jurmed.ro\/medici\/9094-2\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/jurmed.ro\/medici\/9094-2\/\"},\"author\":{\"name\":\"Alina\",\"@id\":\"https:\/\/jurmed.ro\/medici\/#\/schema\/person\/1203ddfc75cb6a85fecd32186ee55582\"},\"headline\":\"Care sunt cele mai noi tratamente \u0219i terapii \u00eempotriva migrenelor?\",\"datePublished\":\"2019-09-13T07:27:12+00:00\",\"dateModified\":\"2019-09-13T08:09:58+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/jurmed.ro\/medici\/9094-2\/\"},\"wordCount\":1085,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/jurmed.ro\/medici\/9094-2\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/jurmed.ro\/medici\/wp-content\/uploads\/sites\/2\/2019\/09\/DR-BOGDAN-PANA.jpg\",\"articleSection\":[\"Cardiologie\",\"Stiri \/ Noutati\"],\"inLanguage\":\"ro-RO\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/jurmed.ro\/medici\/9094-2\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/jurmed.ro\/medici\/9094-2\/\",\"url\":\"https:\/\/jurmed.ro\/medici\/9094-2\/\",\"name\":\"Anticorpi monoclonali, noutatea congresului\",\"isPartOf\":{\"@id\":\"https:\/\/jurmed.ro\/medici\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/jurmed.ro\/medici\/9094-2\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/jurmed.ro\/medici\/9094-2\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/jurmed.ro\/medici\/wp-content\/uploads\/sites\/2\/2019\/09\/DR-BOGDAN-PANA.jpg\",\"datePublished\":\"2019-09-13T07:27:12+00:00\",\"dateModified\":\"2019-09-13T08:09:58+00:00\",\"author\":{\"@id\":\"https:\/\/jurmed.ro\/medici\/#\/schema\/person\/1203ddfc75cb6a85fecd32186ee55582\"},\"description\":\"De\u0219i nu este cea mai frecvent\u0103 form\u0103 de cefalee, migrena este vedeta Congresului Societ\u0103\u021bii Interna\u021bionale a Cefaleei, desf\u0103\u0219urat la Dublin \u00eentre 5 \u0219i 8 septembrie.\",\"breadcrumb\":{\"@id\":\"https:\/\/jurmed.ro\/medici\/9094-2\/#breadcrumb\"},\"inLanguage\":\"ro-RO\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/jurmed.ro\/medici\/9094-2\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ro-RO\",\"@id\":\"https:\/\/jurmed.ro\/medici\/9094-2\/#primaryimage\",\"url\":\"https:\/\/jurmed.ro\/medici\/wp-content\/uploads\/sites\/2\/2019\/09\/DR-BOGDAN-PANA.jpg\",\"contentUrl\":\"https:\/\/jurmed.ro\/medici\/wp-content\/uploads\/sites\/2\/2019\/09\/DR-BOGDAN-PANA.jpg\",\"width\":600,\"height\":450},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/jurmed.ro\/medici\/9094-2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/jurmed.ro\/medici\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Care sunt cele mai noi tratamente \u0219i terapii \u00eempotriva migrenelor?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/jurmed.ro\/medici\/#website\",\"url\":\"https:\/\/jurmed.ro\/medici\/\",\"name\":\"Jurmed - Medici\",\"description\":\"JURMED \u2013 Jurnal de Sanatate este o publicatie lunara de informare si preventie medicala. Revista si site-ul au un continut bogat de articole si informatii cu adresabilitate catre publicul larg.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/jurmed.ro\/medici\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ro-RO\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/jurmed.ro\/medici\/#\/schema\/person\/1203ddfc75cb6a85fecd32186ee55582\",\"name\":\"Alina\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ro-RO\",\"@id\":\"https:\/\/jurmed.ro\/medici\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/6d9f8e49326fb2e29a59f96348688ad5b800d4cee212a8329ed5c51ca5d31570?s=96&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/6d9f8e49326fb2e29a59f96348688ad5b800d4cee212a8329ed5c51ca5d31570?s=96&r=g\",\"caption\":\"Alina\"},\"url\":\"https:\/\/jurmed.ro\/medici\/author\/alinad\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Anticorpi monoclonali, noutatea congresului","description":"De\u0219i nu este cea mai frecvent\u0103 form\u0103 de cefalee, migrena este vedeta Congresului Societ\u0103\u021bii Interna\u021bionale a Cefaleei, desf\u0103\u0219urat la Dublin \u00eentre 5 \u0219i 8 septembrie.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/jurmed.ro\/medici\/9094-2\/","og_locale":"ro_RO","og_type":"article","og_title":"Anticorpi monoclonali, noutatea congresului","og_description":"De\u0219i nu este cea mai frecvent\u0103 form\u0103 de cefalee, migrena este vedeta Congresului Societ\u0103\u021bii Interna\u021bionale a Cefaleei, desf\u0103\u0219urat la Dublin \u00eentre 5 \u0219i 8 septembrie.","og_url":"https:\/\/jurmed.ro\/medici\/9094-2\/","og_site_name":"Jurmed - Medici","article_published_time":"2019-09-13T07:27:12+00:00","article_modified_time":"2019-09-13T08:09:58+00:00","og_image":[{"url":"https:\/\/jurmed.ro\/medici\/wp-content\/uploads\/sites\/2\/2019\/09\/DR-BOGDAN-PANA.jpg","type":"","width":"","height":""}],"author":"Alina","twitter_misc":{"Scris de":"Alina","Timp estimat pentru citire":"5 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/jurmed.ro\/medici\/9094-2\/#article","isPartOf":{"@id":"https:\/\/jurmed.ro\/medici\/9094-2\/"},"author":{"name":"Alina","@id":"https:\/\/jurmed.ro\/medici\/#\/schema\/person\/1203ddfc75cb6a85fecd32186ee55582"},"headline":"Care sunt cele mai noi tratamente \u0219i terapii \u00eempotriva migrenelor?","datePublished":"2019-09-13T07:27:12+00:00","dateModified":"2019-09-13T08:09:58+00:00","mainEntityOfPage":{"@id":"https:\/\/jurmed.ro\/medici\/9094-2\/"},"wordCount":1085,"commentCount":0,"image":{"@id":"https:\/\/jurmed.ro\/medici\/9094-2\/#primaryimage"},"thumbnailUrl":"https:\/\/jurmed.ro\/medici\/wp-content\/uploads\/sites\/2\/2019\/09\/DR-BOGDAN-PANA.jpg","articleSection":["Cardiologie","Stiri \/ Noutati"],"inLanguage":"ro-RO","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/jurmed.ro\/medici\/9094-2\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/jurmed.ro\/medici\/9094-2\/","url":"https:\/\/jurmed.ro\/medici\/9094-2\/","name":"Anticorpi monoclonali, noutatea congresului","isPartOf":{"@id":"https:\/\/jurmed.ro\/medici\/#website"},"primaryImageOfPage":{"@id":"https:\/\/jurmed.ro\/medici\/9094-2\/#primaryimage"},"image":{"@id":"https:\/\/jurmed.ro\/medici\/9094-2\/#primaryimage"},"thumbnailUrl":"https:\/\/jurmed.ro\/medici\/wp-content\/uploads\/sites\/2\/2019\/09\/DR-BOGDAN-PANA.jpg","datePublished":"2019-09-13T07:27:12+00:00","dateModified":"2019-09-13T08:09:58+00:00","author":{"@id":"https:\/\/jurmed.ro\/medici\/#\/schema\/person\/1203ddfc75cb6a85fecd32186ee55582"},"description":"De\u0219i nu este cea mai frecvent\u0103 form\u0103 de cefalee, migrena este vedeta Congresului Societ\u0103\u021bii Interna\u021bionale a Cefaleei, desf\u0103\u0219urat la Dublin \u00eentre 5 \u0219i 8 septembrie.","breadcrumb":{"@id":"https:\/\/jurmed.ro\/medici\/9094-2\/#breadcrumb"},"inLanguage":"ro-RO","potentialAction":[{"@type":"ReadAction","target":["https:\/\/jurmed.ro\/medici\/9094-2\/"]}]},{"@type":"ImageObject","inLanguage":"ro-RO","@id":"https:\/\/jurmed.ro\/medici\/9094-2\/#primaryimage","url":"https:\/\/jurmed.ro\/medici\/wp-content\/uploads\/sites\/2\/2019\/09\/DR-BOGDAN-PANA.jpg","contentUrl":"https:\/\/jurmed.ro\/medici\/wp-content\/uploads\/sites\/2\/2019\/09\/DR-BOGDAN-PANA.jpg","width":600,"height":450},{"@type":"BreadcrumbList","@id":"https:\/\/jurmed.ro\/medici\/9094-2\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/jurmed.ro\/medici\/"},{"@type":"ListItem","position":2,"name":"Care sunt cele mai noi tratamente \u0219i terapii \u00eempotriva migrenelor?"}]},{"@type":"WebSite","@id":"https:\/\/jurmed.ro\/medici\/#website","url":"https:\/\/jurmed.ro\/medici\/","name":"Jurmed - Medici","description":"JURMED \u2013 Jurnal de Sanatate este o publicatie lunara de informare si preventie medicala. Revista si site-ul au un continut bogat de articole si informatii cu adresabilitate catre publicul larg.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/jurmed.ro\/medici\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ro-RO"},{"@type":"Person","@id":"https:\/\/jurmed.ro\/medici\/#\/schema\/person\/1203ddfc75cb6a85fecd32186ee55582","name":"Alina","image":{"@type":"ImageObject","inLanguage":"ro-RO","@id":"https:\/\/jurmed.ro\/medici\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/6d9f8e49326fb2e29a59f96348688ad5b800d4cee212a8329ed5c51ca5d31570?s=96&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6d9f8e49326fb2e29a59f96348688ad5b800d4cee212a8329ed5c51ca5d31570?s=96&r=g","caption":"Alina"},"url":"https:\/\/jurmed.ro\/medici\/author\/alinad\/"}]}},"_links":{"self":[{"href":"https:\/\/jurmed.ro\/medici\/wp-json\/wp\/v2\/posts\/9094","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jurmed.ro\/medici\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jurmed.ro\/medici\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jurmed.ro\/medici\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/jurmed.ro\/medici\/wp-json\/wp\/v2\/comments?post=9094"}],"version-history":[{"count":4,"href":"https:\/\/jurmed.ro\/medici\/wp-json\/wp\/v2\/posts\/9094\/revisions"}],"predecessor-version":[{"id":9104,"href":"https:\/\/jurmed.ro\/medici\/wp-json\/wp\/v2\/posts\/9094\/revisions\/9104"}],"wp:attachment":[{"href":"https:\/\/jurmed.ro\/medici\/wp-json\/wp\/v2\/media?parent=9094"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jurmed.ro\/medici\/wp-json\/wp\/v2\/categories?post=9094"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jurmed.ro\/medici\/wp-json\/wp\/v2\/tags?post=9094"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}