{"id":9446,"date":"2019-10-28T07:30:28","date_gmt":"2019-10-28T07:30:28","guid":{"rendered":"https:\/\/jurmed.ro\/medici\/?p=9446"},"modified":"2019-10-28T07:30:28","modified_gmt":"2019-10-28T07:30:28","slug":"recuperarea-functionala-piciorului-reumatoid","status":"publish","type":"post","link":"https:\/\/jurmed.ro\/medici\/recuperarea-functionala-piciorului-reumatoid\/","title":{"rendered":"Durerea de spate \u00eentr-o nou\u0103 abordare terapeutic\u0103"},"content":{"rendered":"

Autor:<\/strong><\/em><\/p>\n

Dr. Lumini\u021ba Paraschiv,<\/strong><\/em><\/p>\n

Medical Affairs Manager Prisum<\/strong><\/em><\/p>\n

Se estimeaz\u0103 c\u0103 50-90% dintre adul\u0163ii cu v\u00e2rsta sub 45 de ani au experimentat cel pu\u0163in o dat\u0103 \u00een via\u0163\u0103 durerea de spate, cel mai adesea \u00een zona inferioar\u0103 – lombar\u0103\u00b9.<\/p>\n

\u00cen prezent, durerea lombar\u0103 cronic\u0103 este considerat\u0103 din ce \u00een ce mai mult un sindrom mixt, cu component\u0103 at\u00e2t nociceptiv\u0103, c\u00e2t \u0219i neuropat\u0103. De multe ori componenta neuropat\u0103 r\u0103m\u00e2ne neidentificat\u0103 \u0219i netratat\u0103, antiiflamatoarele nesteroidiene \u0219i paracetamolul neav\u00e2nd ac\u021biune asupra acestui tip de durere. (2)<\/sup><\/strong><\/p>\n

\"\"<\/a>Durerea joas\u0103 de spate, recunoscut\u0103 drept principala cauz\u0103 de dizabilitate la nivel mondial, este determinat\u0103 de degenerescen\u021ba discului intervertebral \u00een aproximativ 45% din cazuri (3)<\/sup><\/strong>.<\/p>\n

\u00a0O situa\u021bie similar\u0103 \u00eent\u00e2lnim \u0219i \u00een cazul pacien\u021bilor cu durere cervical\u0103 cronic\u0103, aproape jum\u0103tate din ace\u0219tia prezent\u00e2nd simptome mixte nociceptive \u0219i neuropate sau predominant neuropate. (4)<\/sup><\/p>\n

Anul acesta a fost lansat \u00een Rom\u00e2nia produsul SpineDinamic, ce are la baz\u0103 un concept modern de abordare a neuropatiei periferice \u0219i de restabilire a mobilit\u0103\u021bii coloanei vertebrale. Formula unic\u0103, inovatoare a produsului con\u021bine doze echilibrate de vitamine B1, B6, B12 \u015fi D3, al\u0103turi de nucleotide pirimidinice, citidin\u0103 monofosfat (CMP) \u015fi uridin\u0103 monofosfat (UMP).<\/p>\n

Vitamina B1 are rol important \u00een buna func\u0163ionare a sistemului nervos, protejeaz\u0103 axonii \u015fi \u00eembun\u0103t\u0103\u0163e\u015fte transmiterea impulsului nervos. Vitamina B6 intervine \u00een sinteza neurotransmi\u0163\u0103torilor, dar joac\u0103 \u015fi un rol important, al\u0103turi de vitamina B12, \u00een sinteza tecii de mielin\u0103.<\/p>\n

\"\"<\/a>Conform cercet\u0103rilor recente, vitamina D are ac\u021biune neuroprotectoare \u0219i intervine \u00een regenerarea nervilor. Un studiu experimental ce a urm\u0103rit animale de laborator cu nervul peronier sec\u021bionat a demonstrat c\u0103 vitamina D3 \u00een doze mari induce cre\u0219terea num\u0103rului axonilor, a diametrului acestora \u0219i a gradului de mielinizare, fiind identificate mecanisme de reglarea a expresiei unor gene implicate \u00een procesul de axonogenez\u0103 \u0219i de mielinizare. (5) De asemenea, deficitul vitaminei D a fost corelat cu durerea cronic\u0103 \u0219i cu progresia neuropatiei periferice. Referitor la nivelul vitaminei D \u00een popula\u021bia din \u021bara noastr\u0103, un studiu epidemiolgic desf\u0103\u0219urat pe un e\u0219antion de 6.631 de persoane a ar\u0103tat c\u0103 59% din rom\u00e2ni au deficit sau nivel insuficient de vitamina D. (6)<\/sup><\/strong><\/p>\n

Mai nou, nucleotidele pirimidinice au fost propuse drept solu\u0163ii eficiente\u00a0 pentru refacerea nervilor leza\u021bi, fiind descrise mecanisme certe de ac\u021biune: au rol de molecule semnal \u015fi induc eliberarea factorilor neurotrofici deriva\u021bi din creier, stimuleaz\u0103 proliferarea celulelor Schwann, cre\u015fterea axonilor \u015fi refacerea tecii de mielin\u0103.<\/p>\n

\"\"<\/a>Un studiu clinic ce a urm\u0103rit 400 de pacien\u021bi a demonstrat utilitatea asocierii vitaminei B12 cu nucleotidele\u00a0 pirimidinice \u00een combaterea nevralgiei de tip compresiv. Pacien\u021bii au fost \u00eemp\u0103r\u021bi\u021bi \u00een dou\u0103 loturi: lot A\u00a0 ce a folosit ca tratament vitamina B12 plus combina\u021bia de uridin\u0103 trifosfat-citidin\u0103 monofosfat \u0219i lot B ce a folosit doar vitamina B12 timp de 30 de zile.\u00a0 Valorile \u00eenregistrate pe scala VAS pentru durere au sc\u0103zut \u00een ambele loturi, dar mai semnificativ din punct de vedere statistic \u00een lotul A, ceea ce a demonstrat importan\u021ba asocierii nucleotidelor pirimidinice cu vitamina B12 \u00een combaterea durerii de tip neuropat. (7)<\/sup><\/strong><\/p>\n

Produsul SpineDinamic asigur\u0103 o complian\u0163\u0103 crescut\u0103 la tratament, \u00eentruc\u00e2t doza\u00a0 este de o capsul\u0103 pe zi, iar cutia de 30 de capsule asigur\u0103 tratamentul pentru o lun\u0103. Se recomand\u0103 utilizarea \u00een cure de 3-6 luni, cu posibilitatea repet\u0103rii \u00een caz de nevoie.<\/p>\n

Prin formula inovatoare, SpineDinamic este un produs care merit\u0103 a fi luat \u00een considerare atunci c\u00e2nd se urm\u0103re\u015fte combaterea eficient\u0103 \u015fi f\u0103r\u0103 reac\u0163ii adverse a durerii de spate cu component\u0103 neuropat\u0103 sau a altor forme de neuropatie periferic\u0103.<\/p>\n

Bibliografie<\/strong><\/p>\n

    \n
  1. The Role of Nucleotides in Glial Cells during Peripheral Nerve Trauma and Compressive Disorders Marina Manh\u00e3es et al. 2017- http:\/\/dx.doi.org\/10.5772\/68068<\/li>\n
  2. Neuropathic low back pain in clinical practice- R. Baron et al. – European Journal of Pain 20 (2016) 861–873 .<\/li>\n
  3. Intervertebral disc as a source of pain\u00a0\u2013 W. Rea,\u00a0S. Kapur, H. Mutagi -Continuing Education in Anaesthesia, Critical Care & Pain, Volume 12, Issue 6, 1 December 2012<\/li>\n
  4. Advances in the diagnosis and management of neck pain – Cohen SP,\u00a0Hooten WM – BMJ.\u00a02017 Aug 14;358:j3221.<\/li>\n
  5. Cholecalciferol (Vitamin D3) Improves Myelination and Recovery after Nerve Injury- Jean-Francois Chabas et al. – PLOS ONE | 1 May 2013 | Volume 8 | Issue 5 |<\/li>\n
  6. Vitamin D Status: A Different Story in the Very Young versus the Very Old Romanian Patients – Adela Chirita et al.- PLOS ONE | DOI:10.1371\/ journal.pone.0128010 May 29, 2015<\/li>\n<\/ol>\n

    7. <\/strong>A double-blind, randomized, comparative study of the use of a combination of uridine triphosphate trisodium, cytidine monophosphate disodium and hydroxocobalamin, versus isolated treatment with hydroxocobalamin in patients presenting with compressive neuralgias<\/p>\n","protected":false},"excerpt":{"rendered":"

    Autor: Dr. Lumini\u021ba Paraschiv, Medical Affairs Manager Prisum Se estimeaz\u0103 c\u0103 50-90% dintre adul\u0163ii cu v\u00e2rsta sub 45 de ani au experimentat cel pu\u0163in o dat\u0103 \u00een via\u0163\u0103 durerea de […]<\/p>\n","protected":false},"author":9,"featured_media":9447,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[33,363],"tags":[],"class_list":["post-9446","post","type-post","status-publish","format-standard","has-post-thumbnail","category-articole","category-reabilitare-medicala"],"yoast_head":"\nDurerea de spate \u00eentr-o nou\u0103 abordare terapeutic\u0103<\/title>\n<meta name=\"description\" content=\"Durerea de spate \u00eentr-o nou\u0103 abordare terapeutic\u0103 Autor: Dr. Lumini\u021ba Paraschiv, Medical Affairs Manager Prisum\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jurmed.ro\/medici\/recuperarea-functionala-piciorului-reumatoid\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Durerea de spate \u00eentr-o nou\u0103 abordare terapeutic\u0103\" \/>\n<meta property=\"og:description\" content=\"Durerea de spate \u00eentr-o nou\u0103 abordare terapeutic\u0103 Autor: Dr. Lumini\u021ba Paraschiv, Medical Affairs Manager Prisum\" \/>\n<meta property=\"og:url\" content=\"https:\/\/jurmed.ro\/medici\/recuperarea-functionala-piciorului-reumatoid\/\" \/>\n<meta property=\"og:site_name\" content=\"Jurmed - 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