{"id":9536,"date":"2019-10-31T08:20:19","date_gmt":"2019-10-31T08:20:19","guid":{"rendered":"https:\/\/jurmed.ro\/medici\/?p=9536"},"modified":"2019-10-31T08:20:19","modified_gmt":"2019-10-31T08:20:19","slug":"identificarea-mutatiilor-tinta-cancerul-colorectal-metastatic","status":"publish","type":"post","link":"https:\/\/jurmed.ro\/medici\/identificarea-mutatiilor-tinta-cancerul-colorectal-metastatic\/","title":{"rendered":"Identificarea muta\u0163iilor \u0163int\u0103 \u00een cancerul colorectal metastatic"},"content":{"rendered":"<p style=\"text-align: justify\"><strong><a href=\"https:\/\/jurmed.ro\/medici\/wp-content\/uploads\/sites\/2\/2019\/10\/Top-Diagnostic.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-9537 aligncenter\" src=\"https:\/\/jurmed.ro\/medici\/wp-content\/uploads\/sites\/2\/2019\/10\/Top-Diagnostic-300x59.jpg\" alt=\"\" width=\"321\" height=\"63\" srcset=\"https:\/\/jurmed.ro\/medici\/wp-content\/uploads\/sites\/2\/2019\/10\/Top-Diagnostic-300x59.jpg 300w, https:\/\/jurmed.ro\/medici\/wp-content\/uploads\/sites\/2\/2019\/10\/Top-Diagnostic.jpg 626w\" sizes=\"auto, (max-width: 321px) 100vw, 321px\" \/><\/a>Tehnologia BAT\u00ae<\/strong>&#8211; <strong><u>B<\/u><\/strong>iochip <strong><u>A<\/u><\/strong>rray <strong><u>T<\/u><\/strong>echnology considerat\u0103 tehnologia \u201cGold Standard\u201d pentru testarea multiplex dezvoltat\u0103 de Randox Biosciences, \u00eempreun\u0103 cu platforma <strong>Evidence Investigator,<\/strong> detecteaz\u0103 simultan, calitativ sau cantitativ, o gam\u0103 larg\u0103 de anali\u0163i dintr-o singur\u0103 prob\u0103 biologic\u0103 (s\u00e2nge integral, ser, saliv\u0103, urin\u0103, biopsie \u0163esut).<\/p>\n<p style=\"text-align: justify\">Testarea multiplex revolu\u0163ioneaz\u0103 domeniul de detec\u0163ie molecular, oferind avantaje de neegalat: cre\u0219terea performan\u0163elor clinice, reducere de costuri \u0219i, de asemenea, economie de timp \u0219i resurse.<\/p>\n<p style=\"text-align: justify\"><strong>Cercet\u0103torii de la Randox Biosciences au alocat o aten\u0163ie deosebit\u0103 unei probleme majore de s\u0103n\u0103tate public\u0103 la ora actual\u0103, respectiv managementul cancerului colorectal metastatic.<\/strong><\/p>\n<p style=\"text-align: justify\"><strong>\u00a0<\/strong><\/p>\n<p style=\"text-align: justify\"><strong><u>Detec\u0163ia rapid\u0103 a profilului muta\u0163iilor punctiforme din structura genelor KRAS, BRAF \u0219i PIK3CA<\/u><\/strong><\/p>\n<p style=\"text-align: justify\">\u00cen ciuda recentelor inova\u0163ii terapeutice, prognosticul pacien\u0163ilor cu neoplasm colorectal r\u0103m\u00e2ne rezervat (1 \u2013 Ferlay et al). Neoplasmele metastatice reprezint\u0103 40-50% dintre cazurile nou diagnosticate de cancer colorectal \u0219i se asociaz\u0103 unei morbidit\u0103\u0163i \u00eenalte (1-Ferlay et al, 2). \u00cen ultimii ani s-a demonstrat eficien\u0163a terapeutic\u0103 a anticorpilor monoclonali (moAb) \u00een tratamentul cancerului colorectal metastatic, respectiv cetuximab \u0219i panitumumab, care au ca \u0163int\u0103 receptorul factorului de cre\u0219tere epidermal\u0103 (EGFR) (4 \u2013 Saltz et al, 5 &#8211; Cunningham et al). Ace\u0219ti anticorpi monoclonali (moAb) se folosesc \u00een monoterapie sau asocia\u0163i cu chimioterapicele \u0219i ac\u0163ioneaz\u0103 prin blocarea semnalelor c\u0103ii inhibitorii a EGFR \u00een aval, inclusiv a evenimentelor mediate de genele KRAS, BRAF, PIK3CA. Atunci c\u00e2nd apar muta\u0163ii \u00een stuctura genelor KRAS, BRAF \u0219i PIK3CA acestea sunt activate permanent \u00een aval, f\u0103c\u00e2nd ca terapia anti-EGFR prin moAb s\u0103 devin\u0103 ineficient\u0103. Testul Randox KRAS, BRAF, PIK3CA Array ofer\u0103 medicului oncolog informa\u0163ii cu privire la muta\u0163iile punctiforme importante din structura genelor KRAS, BRAF \u0219i PIK3CA, permi\u0163\u00e2nd astfel selec\u0163ia corect\u0103 a pacien\u0163ilor care pot beneficia de terapia cu anticorpi monoclonali anti-EGFR.<\/p>\n<p style=\"text-align: justify\"><strong><u>\u0162inte detectabile prin testul KRAS, BRAF, PIK3CA* Array <\/u><\/strong><\/p>\n<p style=\"text-align: justify\">Diagnosticul precoce \u0219i detec\u0163ia statusului muta\u0163ional au o importan\u0163\u0103 capital\u0103 pentru identificarea \u0219i selectarea corect\u0103 a pacien\u0163ilor cu cancer colorectal care vor r\u0103spunde poten\u0163ial la terapia cu anticorpi monoclonali.<\/p>\n<p style=\"text-align: justify\"><strong>KRAS, BRAF, PIK3CA Array<\/strong> este un test PCR eficient pentru identificarea rapid\u0103 \u0219i simultan\u0103 a celor mai relevante 20 de muta\u0163ii punctiforme \u00een structura genelor KRAS, BRAF, PIK3CA din ADN extras din \u0163esut proasp\u0103t, \u00eenghe\u0163at sau \u0163esut fixat \u00een parafin\u0103, reduc\u00e2nd astfel necesitatea test\u0103rii reflexe; \u00een tabelul de mai jos se g\u0103sesc \u0163intele detectabile cu ajutorul acestui test:<\/p>\n<p style=\"text-align: justify\"><strong>\u00a0<\/strong><\/p>\n<p style=\"text-align: justify\"><strong><u>De ce este util\u0103 testarea genelor KRAS, BRAF, PIK3CA?<\/u><\/strong><\/p>\n<p style=\"text-align: justify\">Studiile clinice efectuate pe loturi de pacien\u0163i cu neoplasm colorectal metastatic \u0219i care nu au r\u0103spuns la terapia cu chimioterapice, precum \u0219i pe pacien\u0163i care nu au primit chimioterapie, au ar\u0103tat un r\u0103spuns clinic la tratamentul cu anticorpi monoclonali anti-EGFR doar \u00een 10-20% din cazuri (5 &#8211; Cunningham et al., 6 \u2013 Chung et al). Activarea c\u0103ii oncogene a EGFR \u00een aval a fost investigat\u0103 cu privire la eficien\u0163a r\u0103spunsului terapeutic sub tratament cu molecule \u0163intite anti-EGFR. Studiile au confirmat faptul c\u0103 pacien\u0163ii cu neoplasm colorectal metastatic care prezint\u0103 muta\u0163ii punctiforme \u00een structura oncogenelor KRAS nu beneficiaz\u0103 de terapia cu anticorpi monoclonali anti-EGFR (7 \u2013 Lievre et al, 8 \u2013 Benvenuti et al). Literatura de specialitate a recunoscut muta\u0163iile \u00een structura genei KRAS ca factor major de predic\u0163ie negativ\u0103 a eficacit\u0103\u0163ii terapiei cu moAb (cetuximab \u0219i panitumumab) (3 &#8211; Bardelli &amp; Sienna). Prezen\u0163a muta\u0163iilor oncogenei KRAS este responsabil\u0103 \u00eens\u0103 doar pentru 35-45% dintre pacien\u0163ii non-responderi la terapie cu moAb (3 &#8211; Bardelli &amp; Sienna). Devine astfel important\u0103 identificarea unor factori genetici suplimentari care contribuie la apari\u0163ia statusului de rezisten\u0163\u0103 primar\u0103 la agen\u0163ii anti-EGFR: studiile recente s-au concentrat asupra analizei moleculelor implicate \u00een aval \u00een calea semnaliz\u0103rii EGFR, respectiv muta\u0163iile \u00een structura genelor BRAF (9 &#8211; Di Nicolantonio et al.) \u0219i PIK3CA (10 &#8211; De Rook et al.) au fost g\u0103site responsabile pentru r\u0103spunsul alterat al pacien\u0163ilor la terapia \u0163intit\u0103 cu moAb.<\/p>\n<p style=\"text-align: justify\">Top Diagnostics \u00eempreun\u0103 cu parterul s\u0103u Randox Biosciences sus\u0163in diagnosticul molecular \u0219i managementul eficient al pacien\u0163ilor cu cancer colorectal metastatic, prin identificarea rapid\u0103 a celor mai relevante muta\u0163ii \u00een structura oncogenelor KRAS, BRAF, PIK3CA \u0219i prin selectarea corect\u0103 a pacien\u0163ilor eligibili s\u0103 primeasc\u0103 tratament cu molecule \u0163intite anti-EGFR.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tehnologia BAT\u00ae&#8211; Biochip Array Technology considerat\u0103 tehnologia \u201cGold Standard\u201d pentru testarea multiplex dezvoltat\u0103 de Randox Biosciences, \u00eempreun\u0103 cu platforma Evidence Investigator, detecteaz\u0103 simultan, calitativ sau cantitativ, o gam\u0103 larg\u0103 de [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":9537,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[33,168],"tags":[],"class_list":["post-9536","post","type-post","status-publish","format-standard","has-post-thumbnail","category-articole","category-oncologie"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - 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