{"id":7782,"date":"2021-08-03T14:58:09","date_gmt":"2021-08-03T14:58:09","guid":{"rendered":"https:\/\/jurmed.ro\/pacienti\/?p=7782"},"modified":"2021-08-03T14:58:09","modified_gmt":"2021-08-03T14:58:09","slug":"tulburarile-de-somn","status":"publish","type":"post","link":"https:\/\/jurmed.ro\/pacienti\/tulburarile-de-somn\/","title":{"rendered":"Tulbur\u0103rile de somn \u0219i s\u0103n\u0103tatea. Sleep formula – formul\u0103 pentru somn"},"content":{"rendered":"

Somnul pare s\u0103 fie parte inactiv\u0103 a vie\u021bii dar durata \u0219i calitatea somnului joac\u0103 un rol crucial \u00een toate aspectele vie\u021bii active. Somnul este un proces biologic esen\u021bial care ne influen\u021beaz\u0103 sistemul imunitar, func\u021biile creierului, aparatul cardiovascular, activitatea hormonal\u0103, metabolismul, pofta de m\u00e2ncare, greutatea corporal\u0103 \u0219i \u00een final calitatea vie\u021bii.(1,2)<\/sup><\/strong> Cu toate acestea, p\u00e2n\u0103 la 70 de milioane de oameni \u00een SUA \u0219i 45 de milioane din Europa au o tulburare cronic\u0103 a somnului care afecteaz\u0103 func\u021bionarea zilnic\u0103 \u0219i s\u0103n\u0103tatea.(3,4)<\/sup><\/strong><\/p>\n

Lipsa somnului cre\u0219te riscul de cancer, diabet, depresie, infarct miocardic.<\/u><\/strong> Un studiu amplu ce a durat peste 10 ani a urm\u0103rit 78.586 de asistente medicale ce au lucrat \u00een schimburi de noapte. Rezultatele arat\u0103 c\u0103 munca prelungit\u0103 \u00een ture de noapte cre\u0219te mult riscul de cancer colorectal(5)<\/sup><\/strong>.<\/p>\n

Un alt studiu recent desf\u0103surat \u00een Taiwan, a determinat un risc crescut de cancer la pacien\u021bii cu tulbur\u0103ri de somn: insomnie, parasomnie \u0219i apnee obstructiv\u0103 de somn. Riscul de cancer mamar a fost crescut la pacientele cu aceste tipuri de tulbur\u0103ri comparativ cu cele f\u0103r\u0103 tulbur\u0103ri de somn.(6)<\/sup><\/strong> B\u0103rba\u021bii care sufer\u0103 de probleme grave de a somn sunt de dou\u0103 ori mai predispu\u0219i s\u0103 dezvolte cancer de prostat\u0103 dec\u00e2t cei f\u0103r\u0103 insomnie.(7)<\/sup><\/strong> Toate studiile aduc dovezi clare c\u0103 tulburarea somnului este un factor cauzal major \u00een cre\u0219terea stresului, dezvoltarea tulbur\u0103rilor de dispozi\u021bie, a depresiei \u0219i a riscului de suicid.(8)<\/sup><\/strong><\/p>\n

Este dovedit\u0103 asocierea \u00eentre dificultatea de a adormi sau durata scurt\u0103 a somnului \u0219i inciden\u021ba infarctului miocardic, tensiunii arteriale ridicate, afec\u021biunilor cardiovasculare, afectarea sensibilit\u0103\u021bii la insulin\u0103, diabetului de tip 2 \u0219i a obezit\u0103\u021bii. Perturbarea somnului poate agrava simptomele bolii inflamatorii intestinale, a sindromului intestinului iritabil \u0219i a bolii de reflux gastroesofagian.(9)<\/sup><\/strong><\/p>\n

Impactul nociv al lipsei somnului de calitate are drept rezultat cre\u0219terea mortalit\u0103\u021bii \u00een r\u00e2ndul persoanelor cu probleme de somn a\u0219a \u00eenc\u00e2t somnul trebuie sa fie o \u021bint\u0103 terapeutic\u0103 adecvat\u0103. Din p\u0103cate, medicamentele hipnotice au efecte secundare neprev\u0103zute \u0219i utilizarea lor pe termen lung poate duce la rezisten\u021b\u0103 \u0219i dependen\u021b\u0103. Se caut\u0103 compu\u0219i bioactivi din surse naturale cu mai pu\u021bine efecte secundare dar cu eficacitate similar\u0103 medicamentelor hipnotice.<\/p>\n

\"\"<\/a>Formula lipozomal\u0103 pentru inducerea somnului si reducerea stresului.<\/u> <\/strong>Cercet\u0103rile arat\u0103 c\u0103 tulburarea nivelurilor de GABA, de Melatonin\u0103, precum \u0219i a antioxidan\u021bilor vitamina C \u0219i Glutathion sunt direct corela\u021bi cu insomnia \u0219i alte tulbur\u0103ri de somn. GABA (Acidul gamma-aminobutiric), este principalul neurotransmi\u021b\u0103tor inhibitor din creierul mamiferelor. Este un aminoacid neproteic care este larg r\u0103sp\u00e2ndit \u00een natur\u0103. Prin modularea sistemului nervos simpatic \u0219i inhibarea activit\u0103\u021bii neuronale,GABA \u00eembun\u0103t\u0103\u021be\u0219te somnul, reduce stresul mintal \u0219i fizic, scade anxietatea \u0219i ajut\u0103 la recuperarea st\u0103rii de calm \u0219i \u00eembun\u0103t\u0103\u021birea memoriei. GABA permite corpului \u0219i min\u021bii s\u0103 se relaxeze \u0219i s\u0103 doarm\u0103 profund pe tot parcursul nop\u021bii.<\/p>\n

Studiile arat\u0103 c\u0103 nivelurile de GABA la persoanele cu insomnie sunt cu aproape 30% mai mici dec\u00e2t la persoanele f\u0103r\u0103 tulbur\u0103ri de somn. De asemenea, nivelurile sc\u0103zute ale GABA sunt asociate cu un somn nelini\u0219tit, cu treziri dese, instalarea \u0219i men\u021binerea stresului acut \u0219i cronic. Administrarea de GABA pe termen lung (1-8 s\u0103pt\u0103m\u00e2ni) este eficient\u0103 pentru \u00eembun\u0103t\u0103\u021birea parametriilor de somn. Melatonina este un hormon produs \u00een mod natural de organism ce este implicat \u00een reglarea ciclurilor de somn-veghe \u0219i are rol \u00een inducerea somnului. Un simptom al deficien\u021bei de melatonin\u0103 este incapacitatea de a adormi la culcare sau dup\u0103 o eventual\u0103 trezirea pe timpul nop\u021bii.<\/p>\n

\u00centr-un studiu dublu-orb, suplimentarea cu melatonin\u0103 a fost eficient\u0103 pentru reducerea laten\u021bei somnului (timpul necesar adormirii) \u0219i \u00eembun\u0103t\u0103\u021birea calit\u0103\u021bii somnului. Acest lucru a m\u0103rit vigilen\u021b\u0103 \u00een timpul zilei, f\u0103r\u0103 efecte secundare(10)<\/sup><\/strong>.<\/p>\n

Un alt studiu controlat randomizat a ar\u0103tat c\u0103 melatonina este eficient\u0103 \u00een ameliorarea insomniei la 50% din grupul de studiu. Melatonina nu a afectat abilit\u0103\u021bile motorii a doua zi. (11)<\/sup><\/strong><\/p>\n

Melatonina are \u00een plus, rol \u00een repararea ADN-ului, inhibarea cre\u0219terii tumorale \u0219i ac\u021bioneaz\u0103 ca un puternic neutralizant de radicali liberi.(7,12)<\/sup><\/strong> Magneziul activeaz\u0103 sistemul nervos parasimpatic, responsabil pentru dob\u00e2ndirea st\u0103rii de lini\u0219te \u0219i relaxare. Prezen\u021ba unui nivel optim de magneziu m\u0103re\u0219te activitatea neurotransmi\u021b\u0103torului GABA \u0219i ajut\u0103 la reglarea produc\u021biei de melatonin\u0103, func\u021bion\u00e2nd \u00een acela\u0219i timp ca un amortizor al semnalelor sistemului nervos care men\u021bin starea de veghe. Sinergia acidului gamma-aminobutiric, al\u0103turi de melatonin\u0103 \u0219i magneziu \u00een produsul Sleep\u00a0 Formula reprezint\u0103 o compozi\u021bie atent echilibrat\u0103, formulat\u0103 de LipoCellTech\u2122, Marea Britanie, iar \u00eencapsularea \u00een lipozomi naturali, de \u00eenalt\u0103 stabilitate, permit instalarea rapid\u0103 a efectelor terapeutice. Somnul nu este un timp pierdut! Dimpotriv\u0103 este o investi\u021bie \u00een s\u0103n\u0103tatea noastr\u0103 \u0219i ar trebui s\u0103 \u00eei acord\u0103m la fel de mult\u0103 aten\u021bie ca nutri\u021biei \u0219i exerci\u021biilor fizice.<\/p>\n

\n

Referin\u021be:<\/strong><\/p>\n

    \n
  1. Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: Methodology and Discussion.Consensus Conference Panel., Watson NF, Badr MS, Belenky G, Bliwise DL, Buxton OM, Buysse D, Dinges DF, Gangwisch J, Grandner MA, Kushida C, Malhotra RK, Martin JL, Patel SR, Quan SF, Tasali ESleep. 2015 Aug 1; 38(8):1161-83.<\/li>\n
  2. Institute of Medicine, Committee on Sleep Medicine and Research, Board on Health Sciences Policy . Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem. Washington, DC: National Academies Press; 2006.<\/li>\n
  3. Institute of Medicine, Committee on Sleep Medicine and Research, Board on Health Sciences Policy . Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem. Washington, DC: National Academies Press; 2006.<\/li>\n
  4. The economic cost of brain disorders in Europe..Olesen J, Gustavsson A, Svensson M, Wittchen HU, J\u00f6nsson B, CDBE2010 study group., European Brain Council.Eur J Neurol. 2012 Jan; 19(1):155-62.<\/li>\n
  5. Night-shift work and risk of colorectal cancer in the nurses’ health study. Schernhammer ES, Laden F, Speizer FE, Willett WC, Hunter DJ,Kawachi I, Fuchs CS, Colditz GA. J Natl Cancer Inst. 2003 Jun 4; 95(11):825-8.<\/li>\n
  6. \u00a0Risk of Cancer in Patients with Insomnia, Parasomnia, and Obstructive Sleep Apnea: A Nationwide Nested Case-Control Study. Fang HF, Miao NF, Chen CD, Sithole T, Chung MH J Cancer. 2015; 6(11):1140-7.<\/li>\n
  7. Sleep disruption among older men and risk of prostate cancer.Sigurdardottir LG, Valdimarsdottir UA, Mucci LA, Fall K, Rider JR, Schernhammer E, Czeisler CA, Launer L, Harris T, Stampfer MJ, Gudnason V, Lockley SW.Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):872-9.<\/li>\n
  8. Review Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity. Meerlo P, Sgoifo A, Suchecki D. Sleep Med Rev. 2008 Jun; 12(3):197-210.<\/li>\n
  9. Review Sleep, immunity and inflammation in gastrointestinal disorders.Ali T, Choe J, Awab A, Wagener TL, Orr WC World J Gastroenterol. 2013 Dec 28; 19(48):9231-9.<\/li>\n
  10. Patrick Lemoine, Tali Nir, Moshe Laudon, Nava Zisapel, Prolonged release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects, 21 November 2007, Journal of Sleep Research.<\/li>\n
  11. Remy Luthringer, Muriel Muzet, Nava Zisapel, Luc Staner, The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia, PubMed, 2009.<\/li>\n
  12. Short duration of sleep increases risk of colorectal adenoma.Thompson CL, Larkin EK, Patel S, Berger NA, Redline S, Li L Cancer. 2011 Feb 15; 117(4):841-7.<\/li>\n<\/ol>\n

    \n

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    Somnul pare s\u0103 fie parte inactiv\u0103 a vie\u021bii dar durata \u0219i calitatea somnului joac\u0103 un rol crucial \u00een toate aspectele vie\u021bii active. Somnul este un proces biologic esen\u021bial care ne […]<\/p>\n","protected":false},"author":4,"featured_media":7784,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[474,475],"tags":[],"class_list":["post-7782","post","type-post","status-publish","format-standard","has-post-thumbnail","category-medicina-interna","category-stomatologie"],"yoast_head":"\nTulbur\u0103rile de somn \u0219i s\u0103n\u0103tatea. 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