{"id":7877,"date":"2021-08-31T13:49:49","date_gmt":"2021-08-31T13:49:49","guid":{"rendered":"https:\/\/jurmed.ro\/pacienti\/?p=7877"},"modified":"2021-08-31T13:49:49","modified_gmt":"2021-08-31T13:49:49","slug":"vitamina-b12","status":"publish","type":"post","link":"https:\/\/jurmed.ro\/pacienti\/vitamina-b12\/","title":{"rendered":"Vitamina\u00a0B12 Importan\u021ba ei \u00een anemie, imunitate \u0219i s\u0103n\u0103tate celular\u0103"},"content":{"rendered":"

Deficien\u021ba vitaminei B12 este destul de frecvent\u0103, cu prec\u0103dere \u00een urm\u0103toarele situa\u021bii: \u00eenaintarea \u00een v\u00e2rst\u0103, anemii megaloblastice, urmarea unei diete vegane, afec\u021biuni sau interven\u021bii chirurgicale la nivelul tractului gastrointestinal, consumul frecvent de substan\u021be medicamentoase sau de alcool, perioada de sarcin\u0103 \u0219i al\u0103ptare. <\/strong><\/p>\n

Printre simptomele caren\u021bei de vitamina B12 putem include: anemie, paloare, constipa\u021bie, dispnee, afectarea apetitului, pierdere \u00een greutate, oboseal\u0103, nuan\u021b\u0103 de galben \u00een albul ochiului, amor\u021beli, furnic\u0103turi la nivelul membrelor, dezechilibru al st\u0103rii mentale, declin cognitiv, cea\u021b\u0103 mental\u0103, sl\u0103birea memoriei, ulcere bucale, durerea \u0219i inflama\u021bia limbii (glosit\u0103).<\/p>\n

Pentru a fi asimilat\u0103, vitamina B12 are nevoie de ceea ce numim factorul intrinsec, o glicoprotein\u0103 secretat\u0103 de celulele parietale din regiunea fundic\u0103 a stomacului. Afectarea factorului intrinsec \u00een sine \u0219i a func\u021biei acestuia este cauzat\u0103 de: gastrite atrofice, alimenta\u021bie procesat\u0103, toxicitate, metale grele, alcool, intoleran\u021b\u0103 la gluten, boala celiac\u0103, boala Crohn, infec\u021bia cu helicobacter Pylori, hipoclorhidrie, parazitoze, disbioz\u0103 intestinal\u0103, intestin permeabil \u0219i\/sau iritabil.<\/p>\n

\"\"<\/a>Vitamina B12 este crucial\u0103 pentru func\u021bionarea sistemului imunitar.Deficitul de B12 duce la un num\u0103r redus de limfocite \u0219i afecteaz\u0103 activitatea celulelor Natural Killer (celule citotoxice care ac\u021bioneaz\u0103 rapid \u00eempotriva celulelor infectate viral \u0219i a celulelor tumorale) [1]<\/sup><\/strong>.<\/p>\n

De asemenea, vitamina B12 determin\u0103 formarea de globule ro\u0219ii \u0219i contribuie la men\u021binerea unui nivel optim de fier \u00een organism. Cu toate acestea, simptomele neurologice ale deficitului de vitamina B12 pot ap\u0103rea f\u0103r\u0103 anemie, astfel \u00eenc\u00e2t diagnosticarea \u0219i interven\u021bia timpurie sunt importante pentru a evita deteriorarea ireversibil\u0103[2]<\/sup><\/strong>.<\/p>\n

Metilcobalamina, forma activ\u0103 a vitaminei B12 \u00een structur\u0103 lipozomal\u0103<\/u><\/strong><\/p>\n

LipoCellTechTM<\/sup> cu sediul \u00een Marea Britanie, a reu\u0219it brevetarea unei tehnologii de ob\u021binere complet natural\u0103 a microsferelor lipozomale stabile, f\u0103r\u0103 folosirea presiunilor sau a temperaturilor ridicate, f\u0103r\u0103 ad\u0103ugarea de substan\u021be inactive, alcool sau conservan\u021bi.<\/p>\n

Formulele lipozomale realizate prin aceast\u0103 metod\u0103 asigur\u0103 o absorb\u021bie a substan\u021belor active de 20 de ori mai mare dec\u00e2t \u00een cazul suplimentelor clasice.<\/p>\n

Un nivel plasmatic redus, diagnosticat prin analiz\u0103 medical\u0103, poate fi corelat cu un risc crescut de cancer. Cu toate acestea, la un num\u0103r considerabil de pacien\u021bi cu diferite forme de cancer sau alte afec\u021biuni cronice de natur\u0103 inflamatorie[3]<\/sup><\/strong> s-au g\u0103sit niveluri ridicate de vitalina B12 \u00een fluxul sanguin. Acest antagonism se datoreaz\u0103 faptului c\u0103 deficien\u021ba de vitamina B12 poate fi prezent\u0103 chiar dac\u0103 exist\u0103 niveluri serice ridicate. O astfel de situa\u021bie indic\u0103 o dificultate clar\u0103 de absorb\u021bie a vitaminei B12 la nivel celular. Pacien\u021bii suspecta\u021bi clinic de deficit dar cu un nivel seric de vitamina B12 \u00een limite normale trebuie s\u0103 fie investiga\u021bi cu alte teste, cum ar fi holotranscobalamina (vitamina B12 activ\u0103), homocisteina plasmatic\u0103 sau acidul metilmalonic seric.<\/p>\n

Metilcobalamina poate penetra cu u\u0219urin\u021b\u0103 bariera hemato-encefalic\u0103, iar \u00eencapsularea sa \u00een lipozomi naturali, de \u00eenalt\u0103 stabilitate, confer\u0103 o absorb\u021bie la nivel celular de p\u00e2n\u0103 la 99%[3]<\/sup><\/strong>.<\/p>\n

\u00cen Rom\u00e2nia, formularea lipozomal\u0103 pur\u0103 a vitaminei B12 de c\u0103tre LipoCellTechTM <\/sup>se g\u0103se\u0219te sub denumirea de Lipozomal Vitamina B12 + D-Riboz\u0103 Hypernatura\u00ae<\/sup>.<\/p>\n

D-Riboza este un element constitutiv al macromoleculelor de ADN \u0219i ARN, fiind folosit de toate celulele organismului \u00een procesul de produc\u021bie a energiei celulare (ATP). Este recomandat persoanelor diagnosticate cu fibromialgie sau sindrom de oboseal\u0103 cronic\u0103, dar \u0219i sportivilor de performan\u021b\u0103 pentru cresterea energiei \u0219i anduran\u021bei.<\/p>\n

Vitamina B12 \u0219i D-Riboza ac\u021bioneaz\u0103 sinergic \u00een sintetizarea corect\u0103 a ADN-ului, replicarea ARN-ului, protejarea \u00eempotriva defectelor de tub neural \u00een timpul sarcinii, sus\u021binerea sistemului imunitar \u0219i protejarea de infec\u021bii prin reglarea activit\u0103\u021bii limfocitelor B \u0219i T \u0219i a celulelor NK, dezvoltarea optim\u0103 a creierului \u0219i a sistemului nervos, sus\u021binerea aten\u021biei \u0219i memoriei, reducerea oboselii, producerea de energie, formarea \u0219i regenerarea celulelor ro\u0219ii.<\/p>\n

\n

Referin\u021be:<\/strong><\/p>\n

[1]<\/strong>\u00a0\u00a0 Tamura J, Kubota K, Murakami H, Sawamura M, Matsushima T, Tamura T, et al. Immunomodulation by vitamin B12: Augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment, 1999;<\/p>\n

[2]\u00a0\u00a0 <\/strong>Clarke R. B-vitamins and prevention of dementia. Proc Nutr Soc 2008; (https:\/\/pubmed.ncbi.nlm.nih.gov\/18234134\/);<\/p>\n

[3]\u00a0\u00a0 <\/strong>Chiche L, Jean R, Romain F, Roux F, Thomas G, Canavese S, et al. Clinical implications of high cobalamin blood levels for internal medicine. Rev Med Interne. 2008<\/p>\n

[4]\u00a0\u00a0 <\/strong>Akbarzadeh, A., Rezaei-Sadabady, R., Davaran, S., Joo, S. W., Zarghami, N., et al. (2013). Liposome: classification, preparation, and applications. Nanoscale research letters.<\/p>\n","protected":false},"excerpt":{"rendered":"

Deficien\u021ba vitaminei B12 este destul de frecvent\u0103, cu prec\u0103dere \u00een urm\u0103toarele situa\u021bii: \u00eenaintarea \u00een v\u00e2rst\u0103, anemii megaloblastice, urmarea unei diete vegane, afec\u021biuni sau interven\u021bii chirurgicale la nivelul tractului gastrointestinal, consumul […]<\/p>\n","protected":false},"author":4,"featured_media":7879,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[471],"tags":[],"class_list":["post-7877","post","type-post","status-publish","format-standard","has-post-thumbnail","category-medicina-de-familie"],"yoast_head":"\nVitamina\u00a0B12 Importan\u021ba ei \u00een anemie, imunitate \u0219i s\u0103n\u0103tate celular\u0103 - Jurmed - Pacienti<\/title>\n<meta name=\"description\" content=\"Deficien\u021ba vitaminei B12 este destul de frecvent\u0103 in cazul \u00eenaintarii \u00een v\u00e2rst\u0103, anemii megaloblastice, urmarea unei diete vegane,\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jurmed.ro\/pacienti\/vitamina-b12\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vitamina\u00a0B12 Importan\u021ba ei \u00een anemie, imunitate \u0219i s\u0103n\u0103tate celular\u0103 - 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