{"id":8205,"date":"2022-01-10T12:40:22","date_gmt":"2022-01-10T12:40:22","guid":{"rendered":"https:\/\/jurmed.ro\/pacienti\/?p=8205"},"modified":"2022-01-10T12:40:22","modified_gmt":"2022-01-10T12:40:22","slug":"hepatoprotectia-o-necesitate-in-infectiile-respiratorii","status":"publish","type":"post","link":"https:\/\/jurmed.ro\/pacienti\/hepatoprotectia-o-necesitate-in-infectiile-respiratorii\/","title":{"rendered":"Hepatoprotec\u021bia, o necesitate \u00een\u00a0infec\u0163iile respiratorii?"},"content":{"rendered":"
\"\"<\/a>
Autor: Dr. Lumini\u021ba Paraschiv, Medical Affairs Manager Prisum<\/em><\/figcaption><\/figure>\n

\u00cen timpul unei infec\u0163ii respiratorii, ne g\u00e2ndim, \u00een primul r\u00e2nd, la tratamente care s\u0103 combat\u0103 manifest\u0103rile bolii, astfel \u00eenc\u00e2t s\u0103 sc\u0103p\u0103m c\u00e2t mai repede de febr\u0103, durere \u015fi tuse.\u00a0 Ne preocup\u0103 mai pu\u0163in protec\u0163ia ficatului, de\u015fi consecin\u0163ele afect\u0103rii hepatice \u00een acest context pot fi dramatice. <\/strong><\/p>\n

\u00cen perioadele cu inciden\u021b\u0103 mare a infec\u0163iilor respiratorii, cre\u015fte consumul medicamentelor menite s\u0103 combat\u0103 simptomele acestor boli, de tipul antitermicelor,\u00a0 analgezicelor \u015fi\u00a0 antiinflamatoarelor, dar \u015fi al antibioticelor \u0219i antiviralelor, ce au rol \u00een anihilarea patogenilor.<\/p>\n

Utilizarea acestor medicamente \u00een doze mari sau \u00een asociere poate conduce la afectarea ficatului. De\u015fi sunt fenomene\u00a0 destul de rare, leziunile hepatice induse medicamentos devin periculoase prin formele grave pe care le pot \u00eembr\u0103ca.<\/p>\n

\u00a0Ficatul este organul unde sunt metabolizate majoritatea medicamentolor \u015fi\u00a0 substan\u0163elor toxice, rezult\u00e2nd substan\u0163e lipsite de toxicitate care vor fi eliminate ulterior din corp. \u00cen acest proces vital numit detoxifiere hepatic\u0103 ficatul poate suferi daune, mai ales dac\u0103 este vorba de o cantitate mare de\u00a0 toxice sau dac\u0103 exist\u0103 deja o suferin\u0163\u0103 hepatic\u0103.<\/p>\n

P\u00e2n\u0103 \u00een prezent au fost identificate peste 1.000 de medicamente cu poten\u021bial hepatotoxic.1<\/sup><\/strong> Multe dintre ele sunt medicamente pe care le folosim \u00een mod uzual, precum paracetamolul. Dar iat\u0103 c\u0103 abuzul de\u00a0 paracetamol reprezint\u0103 ast\u0103zi\u00a0 principala cauz\u0103 a insuficien\u021bei hepatice acute \u00een \u021b\u0103rile dezvoltate.2<\/sup><\/strong><\/p>\n

\"\"<\/a>Alte medicamente hepatotoxice destul de des utilizate sunt antibioticele \u015fi antiviralele.\u00a0 \u00centr-un studiu care a urm\u0103rit 899 de pacien\u0163i cu afectare hepatic\u0103 indus\u0103 de medicamente (excluz\u00e2nd paracetamolul) s-a demonstratat c\u0103 45% dintre medicamentele incriminate erau antimicrobienele, \u00een special antibioticele. Cele mai multe cazuri au fost generate de combina\u0163ia amoxicilin\u0103-acid clavulanic, \u00een timp ce azitromicina a reprezentat medicamentul cu cel mai mare risc\u00a0 de toxicitatea hepatic\u0103 la pacien\u0163ii care aveau deja\u00a0 afec\u0163iuni hepatice. Din totalul pacien\u0163ilor, 10% au dezvoltat forme de afectare hepatic\u0103 extrem de grave, ce au condus la deces sau la necesitatea transplantului hepatic, \u00een timp ce al\u0163i 17.5% au dob\u00e2ndit o form\u0103 cronic\u0103.3<\/sup><\/strong><\/p>\n

\u00a0\u00cen cazul pacien\u0163ilor cu COVID-19, aproximativ jum\u0103tate dintre cei spitaliza\u0163i prezint\u0103 semne de afectare hepatic\u0103, datorat\u0103, \u00een principal, agresiunii directe a virusului sau toxi-cit\u0103\u0163ii medicamentoase.\u2074<\/strong><\/p>\n

\u00a0\u00centr-un review realizat de o echip\u0103 de cercet\u0103tori din Statele Unite, care a urm\u0103rit mecanismele afect\u0103rii\u00a0 ficatului \u00een cazul infec\u0163iei cu SARS-COV-2, au fost analizate \u015fi recomandate o serie de plante medicinale hepatoprotectoare, printre care cicoarea \u015fi caperul. 5<\/sup><\/strong><\/p>\n

\u00a0Cicoarea (Cichorium intybus) denumit\u0103 de marele medic al antichit\u0103\u0163ii, Galenus, drept „prieten al ficatului”, ofer\u0103 protec\u0163ie ficatului\u00a0 \u00een caz de toxicitate indus\u0103 de medicamente, alcool \u015fi substan\u0163e toxice, neutraliz\u00e2nd radicalii liberi prin aportul mare de antioxidan\u0163i.<\/p>\n

Caperul (Capparis spinosa) este un arbust cunoscut mai mult pentru bobocii \u015fi fructele sale, caperele, utilizate \u00een alimenta\u0163ie. Extractul de Capparis spinosa exercit\u0103, \u00eens\u0103, un important rol hepatoprotector\u00a0 prin con\u0163inutul bogat de substan\u0163e antiinflamatoare \u015fi antioxidante de tipul polifenolilor, flavonoidelor, carotenoidelor, tocoferolului.<\/p>\n

Includerea hepatoprotectoarele \u00een schema de tratament a infec\u0163iilor respiratorii devine o necesitate de multe ori, iar utilizarea produselor cu eficacitate \u015fi siguran\u0163\u0103 dovedite \u015ftiin\u0163ific reprezint\u0103 \u00eentotdeauna o bun\u0103 alegere.<\/p>\n

\n

    \n
  1. Drug-induced liver injury: Do we know everything? Alempijevic T. Et al., World J. Hepatol. Apr 8, 2017; 9 (10):491-502<\/li>\n
  2. Acetaminophen-induced Acute Liver Failure Is More Common and More Severe in Women. Rubin J.B. Et al., Clin. Gastroenterol Hepatol. 2018 June; 16(6):936-946<\/li>\n
  3. Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study -N. Chalasani et al. – Gastroenterology 2015;148:1340\u20131352<\/li>\n
  4. SARS-CoV-2 another kind of liver aggressor, how does it do that? S.A. Lozano-Sepulveda et al. \/ Annals of Hepatology 19 (2020) 590\u2013594<\/li>\n
  5. Role of Nutraceuticals in COVID-19 Mediated Liver Dysfunction \u2013 M. Sikander et al.- Molecules 2020 Dec 13;25(24):5905.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u00cen timpul unei infec\u0163ii respiratorii, ne g\u00e2ndim, \u00een primul r\u00e2nd, la tratamente care s\u0103 combat\u0103 manifest\u0103rile bolii, astfel \u00eenc\u00e2t s\u0103 sc\u0103p\u0103m c\u00e2t mai repede de febr\u0103, durere \u015fi tuse.\u00a0 Ne […]<\/p>\n","protected":false},"author":4,"featured_media":6902,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[474],"tags":[],"class_list":["post-8205","post","type-post","status-publish","format-standard","has-post-thumbnail","category-medicina-interna"],"yoast_head":"\nHepatoprotec\u021bia, o necesitate \u00een\u00a0infec\u0163iile respiratorii? - Jurmed - Pacienti<\/title>\n<meta name=\"description\" content=\"Hepatoprotec\u021bia este foarte importanta in cazul utilizarii de medicamente \u00een doze mari sau \u00een asociere poate conduce la afectarea ficatului\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jurmed.ro\/pacienti\/hepatoprotectia-o-necesitate-in-infectiile-respiratorii\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hepatoprotec\u021bia, o necesitate \u00een\u00a0infec\u0163iile respiratorii? 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